Discovery through Partnership | Excellence through Quality
| Product Name | Clozapine N-oxide |
| Description |
Activator of DREADDs |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 34233-69-7 |
| Molecular Formula | C18H19ClN4O |
| Molecular Weight | 342.8 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | May be dissolved in DMSO (15 mg/ml); or ethanol (3 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow powder |
| SMILES | ClC(C=C3)=CC1=C3NC(C=CC=C2)=C2C(N4CC[N+](C)([O-])CC4)=N1 |
| InChI | InChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 |
| InChIKey | WYRDWWAASBTJLM-UHFFFAOYSA-N |
| Safety Phrases | GHS Classification: GHS06 Acute toxicity (oral, dermal, inhalation), categories 1,2,3 Hazard statement(s): H301-H336 |
| Cite This Product | Clozapine N-oxide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-570) |
Biological Description
| Alternative Names | 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
| Research Areas | Cell Signaling, G Protein Signaling, GPCR, Neuroscience, Neurotransmission |
| PubChem ID | 2819 |
| Scientific Background | Clozapine N-oxide (CNO) is a pharmacologically inert compound that selectively activates designer receptors exclusively activated by designer drugs (DREADDs). In neuroscience, CNO is widely used in chemogenetic studies to modulate neuronal activity with high spatial and temporal precision. It enables researchers to investigate neural circuits underlying behavior, cognition, and neurodegenerative processes by selectively activating or inhibiting specific neuronal populations. |
Product Images
Chemical structure of Clozapine N-Oxide (SIH-570), a Activator of DREADDs. CAS #: 34233-69-7. Molecular Formula: C18H19ClN4O. Molecular Weight: 342.8 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.