Clozapine N-oxide

Activator of DREADDs

Catalog No. SIH-570

0 out of 5 based on 0 customer ratings
CAS No. 34233-69-7
Molecular Formula C18H19ClN4O
SKU: SIH-570 Categories: ,

Clear
SIH-570-Clozapine-N-Oxide-Chemical-Structure.png
Product Name Clozapine N-oxide
Description

Activator of DREADDs

Purity >98% (TLC); NMR (Conforms)
CAS No. 34233-69-7
Molecular Formula C18H19ClN4O
Molecular Weight 342.8
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Activator
Solubility May be dissolved in DMSO (15 mg/ml); or ethanol (3 mg/ml)
Source Synthetic
Appearance Yellow powder
SMILES ClC(C=C3)=CC1=C3NC(C=CC=C2)=C2C(N4CC[N+](C)([O-])CC4)=N1
InChI InChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChIKey WYRDWWAASBTJLM-UHFFFAOYSA-N
Safety Phrases GHS Classification: GHS06 Acute toxicity (oral, dermal, inhalation), categories 1,2,3 Hazard statement(s): H301-H336
Cite This Product Clozapine N-oxide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-570)

Biological Description

Alternative Names 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Research Areas Cell Signaling, G Protein Signaling, GPCR, Neuroscience, Neurotransmission
PubChem ID 2819
Scientific Background Clozapine N-oxide (CNO) is a pharmacologically inert compound that selectively activates designer receptors exclusively activated by designer drugs (DREADDs). In neuroscience, CNO is widely used in chemogenetic studies to modulate neuronal activity with high spatial and temporal precision. It enables researchers to investigate neural circuits underlying behavior, cognition, and neurodegenerative processes by selectively activating or inhibiting specific neuronal populations.

Product Images

<p>Chemical structure of Clozapine N-Oxide (SIH-570), a Activator of DREADDs. CAS #: 34233-69-7. Molecular Formula: C18H19ClN4O. Molecular Weight: 342.8 g/mol.</p>

Chemical structure of Clozapine N-Oxide (SIH-570), a Activator of DREADDs. CAS #: 34233-69-7. Molecular Formula: C18H19ClN4O. Molecular Weight: 342.8 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “Clozapine N-oxide”

Your email address will not be published. Required fields are marked *