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| Product Name | Cyclothiazide |
| Description |
AMPA receptor desensitization inhibitor |
| Purity | >98% (HPLC/TLC); NMR (conforms) |
| CAS No. | 2259-96-3 |
| Molecular Formula | C14H16ClN3O4S2 |
| Molecular Weight | 389.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (35 mg/ml); or ethanol (9 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | NS(=O)(=O)C1=C(Cl)C=C2NC(NS(=O)(=O)C2=C1)C1CC2CC1C=C2 |
| InChI | InChI=1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20) |
| InChIKey | BOCUKUHCLICSIY-UHFFFAOYSA-N |
| Safety Phrases |
Hazard statement(s): H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary statement(s): P260 Do not breathe dust/fume/gas/mist/vapours/spray P264 Wash hands thoroughly after handling P280 Wear protective gloves/protective clothing/eye protection/face protection P302+352 IF ON SKIN: Wash with soap and water P304+340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing P305+351+338 IF IN EYES: Rinse continuously with water for several minutes. Remove contact lenses if present and easy to do so - continue rinsing P333+313 If skin irritation or a rash occurs: Get medical advice/attention |
| Cite This Product | Cyclothiazide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-574) |
Biological Description
| Alternative Names | 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide; LY-35483 |
| Research Areas | AMPA Receptors, Glutamate Receptors, Neuroscience, Neurotransmission, Neurotransmitter Receptors |
| PubChem ID | 2910 |
| Scientific Background | Cyclothiazide is a positive allosteric modulator of AMPA receptors that enhances excitatory synaptic transmission by inhibiting receptor desensitization. In neuroscience, it is used to study synaptic plasticity, learning, and memory. Cyclothiazide is also employed in models of epilepsy and excitotoxicity to investigate the role of glutamatergic signaling in neuronal survival and death. Its ability to potentiate AMPA receptor activity makes it a valuable compound for exploring excitatory neurotransmission and its dysregulation in neurodegenerative diseases. |
Product Images
Chemical structure of Cyclothiazide (SIH-574), a AMPA Receptor Modulator. CAS #: 2259-96-3. Molecular Formula: C14H16ClN3O4S2. Molecular Weight: 389.9 g/mol.
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