Erlotinib Hydrochloride

EGFR Kinase inhibitor

Catalog No. SIH-444

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CAS No. 183319-69-9
Molecular Formula C22H24ClN3O4
SKU: SIH-444 Categories: ,

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SIH-444_Erlotinib_Hydrochloride_Chemical_Structure.png
Product Name Erlotinib Hydrochloride
Description

EGFR Kinase inhibitor

Purity >99%
CAS No. 183319-69-9
Molecular Formula C22H24ClN3O4
Molecular Weight 429.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO at 18 mg/ml with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Source Synthetic
Appearance Solid powder
SMILES [H+].C1=C(OCCOC)C(=CC2=NC=NC(=C12)NC3=CC(=CC=C3)C#C)OCCOC.[Cl-]
InChI InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
InChIKey GTTBEUCJPZQMDZ-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Erlotinib Hydrochloride (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-444)

Biological Description

Alternative Names N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 176871
Scientific Background Erlotinib Hydrochloride is a selective inhibitor of the epidermal growth factor receptor (EGFR/HER-1) tyrosine kinase. In neuroscience, EGFR signaling has been implicated in neuroinflammation, gliogenesis, and blood-brain barrier integrity. Erlotinib is used to explore the role of EGFR in neural cell proliferation, survival, and response to injury. Its ability to modulate receptor tyrosine kinase activity makes it a useful compound in studying neurovascular remodeling and neurodegenerative disease mechanisms involving aberrant EGFR signaling.
References 1. Ali S., et al. (2008) Mol. Cancer Ther. 7(6): 1708–1719.

Product Images

<p>Chemical structure of Erlotinib Hydrochloride (SIH-444), a EGFR Kinase inhibitor. CAS #: 183319-69-9. Molecular Formula: C22H24ClN3O4. Molecular Weight: 429.9 g/mol.</p>

Chemical structure of Erlotinib Hydrochloride (SIH-444), a EGFR Kinase inhibitor. CAS #: 183319-69-9. Molecular Formula: C22H24ClN3O4. Molecular Weight: 429.9 g/mol.

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