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| Product Name | HC-030031 |
| Description |
TRPA1 blocker |
| Purity | >98% |
| CAS No. | 349085-38-7 |
| Molecular Formula | C18H21N5O3 |
| Molecular Weight | 355.39 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C |
| InChI | InChI=1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24) |
| InChIKey | HEQDZPHDVAOBLN-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H301 Precautionary Phrases: P301 + P310 |
| Cite This Product | HC-030031 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-303) |
Biological Description
| Alternative Names | 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide |
| Research Areas | Ion Channels, Neuroscience |
| PubChem ID | 1150897 |
| Scientific Background | HC-030031 is a selective TRPA1 channel blocker that inhibits calcium influx triggered by irritants such as AITC and formalin. It does not affect other TRP channels or ion channels like TRPV1, TRPV3, TRPV4, hERG, or Nav1.2. In neuroscience, HC-030031 is used to investigate TRPA1's role in pain perception, neuroinflammation, and its potential involvement in neurodegenerative conditions characterized by oxidative stress. |
| References |
1. McNamara C.R., et al. (2007) Proc Natl Acad Sci USA. 104(33): 13525-13530. 2. Taylor-Clark T.E., et al. (2008) Mol Pharmacol. 73(2): 274-281. |
Product Images
Chemical structure of HC-030031 (SIH-303), a TRPA1 blocker. CAS #: 349085-38-7. Molecular Formula: C18H21N5O3. Molecular Weight: 355.39 g/mol.
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