Herbimycin A

Hsp90 inhibitor

Catalog No. SIH-116

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CAS No. 70563-58-5
Molecular Formula C30H42N2O9
SKU: SIH-116 Categories: ,

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SIH-116_Herbimycin_A_Chemical_Structure.png
Product Name Herbimycin A
Description

Hsp90 inhibitor

Purity >98%
CAS No. 70563-58-5
Molecular Formula C30H42N2O9
Molecular Weight 574.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)
Source Synthetic
Appearance Yellow Solid
SMILES C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C=C([C@@H]1OC)C2=O)/C)OC)OC(=O)N)C)C)OC)OC
InChI InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(
InChIKey MCAHMSDENAOJFZ-BVXDHVRPSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Herbimycin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-116)

Biological Description

Alternative Names [(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
Research Areas Cancer, Heat Shock
PubChem ID 6436247
Scientific Background Herbimycin A is a benzoquinoid ansamycin antibiotic known for its irreversible inhibition of tyrosine kinases through thiol group interaction. While predominantly studied in oncology, Herbimycin A’s ability to modulate kinase signaling cascades positions it as a candidate for neurodegenerative disease research. Tyrosine kinases play critical roles in neuronal survival, synaptic plasticity, and neuroinflammation. By inhibiting kinases such as Src and Abl, Herbimycin A may help attenuate aberrant signaling associated with neurodegenerative conditions. Its potential to influence phospholipase C activity and downstream pathways further supports its relevance in neuroscience, particularly in the context of cellular stress responses and neuroprotection.
References 1. Uehara Y., and Fukazawa H. (1991) Methods Enzymol. 201: 370.
2. Fukazawa H., et al. (1991) Biochem. Pharmacol. 42: 1661.
3. Satoh T., et al. (1992) J.Biol.Chem. 267: 2537.
4. Weiss R., and Nuccitelli R. (1992) J.Biol.Chem. 267:5608.

Product Images

<p>Chemical structure of Herbimycin A (SIH-116), a Hsp90 inhibitor. CAS #: 70563-58-5. Molecular Formula: C30H42N2O9. Molecular Weight: 574.3 g/mol.</p>

Chemical structure of Herbimycin A (SIH-116), a Hsp90 inhibitor. CAS #: 70563-58-5. Molecular Formula: C30H42N2O9. Molecular Weight: 574.3 g/mol.

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