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| Product Name | IU1 |
| Description |
Usp-14 inhibitor |
| Purity | >98% |
| CAS No. | 314245-33-5 |
| Molecular Formula | C18H21FN2O |
| Molecular Weight | 300.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 30 mg/ml DMSO, 15 mg/ml Ethanol |
| Source | Synthetic |
| Appearance | Beige Solid |
| SMILES | CC1=CC(=C(N1C2=CC=C(C=C2)F)C)C(=O)CN3CCCC3 |
| InChI | InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3 |
| InChIKey | JUWDSDKJBMFLHE-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H303 – May be harmful if swallowed H318 – Causes serious eye damage Precautionary Statements: P280 – Wear protective gloves/ eye protection/ face protection P305 + P351 + P338 – If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses. |
| Cite This Product | IU1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-329) |
Biological Description
| Alternative Names | 1-[1-(4-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-pyrrolidin-1-yl-ethanone |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 675434 |
| Scientific Background | IU1 is a selective inhibitor of the deubiquitinating enzyme Usp14, enhancing proteasome activity and substrate proteolysis. In neurodegenerative disease research, IU1 is utilized to promote clearance of misfolded proteins, supporting studies on proteostasis and therapeutic strategies aimed at reducing toxic protein aggregates in neural cells. |
| References |
1. Lee B.H., et al. (2010) Nature 467: 1179. 2. Lee B.H., et al. (2010) Mol. Cell. Proteomics 10: R1100003871. |
Product Images
Chemical structure of IU1 (SIH-329), a Usp-14 inhibitor. CAS #: 314245-33-5. Molecular Formula: C18H21FN2O . Molecular Weight: 300.4 g/mol.
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