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| Product Name | JX 401 |
| Description |
p38 MAP kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 349087-34-9 |
| Molecular Formula | C21H25NO2S |
| Molecular Weight | 355.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (20 mg/ml) or ethanol (10 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white solid |
| SMILES | COC1=C(C=CC(=C1)SC)C(=O)N2CCC(CC2)CC3=CC=CC=C3 |
| InChI | InChI=1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3 |
| InChIKey | OMGLGPKQUFSRNN-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | JX 401 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-454) |
Biological Description
| Alternative Names | 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 1126109 |
| Scientific Background | JX 401 is a potent and reversible inhibitor of p38α mitogen-activated protein kinase (MAPK), a key regulator of inflammatory responses and cellular stress signaling. In neurodegenerative disease research, p38α MAPK is implicated in microglial activation, cytokine production, and neuronal apoptosis. JX 401 is used to investigate the role of p38α in neuroinflammation and neurotoxicity, particularly in models of Alzheimer's disease, Parkinson's disease, and traumatic brain injury. Its cell-permeable nature and specificity make it a valuable tool for dissecting MAPK signaling pathways in the central nervous system. |
| References | 1. Friedmann Y., et al. (2006) Mol. Pharm. 70(4): 1395–1405. |
Product Images
Chemical structure of JX 401 (SIH-454), a p38alpha MAP kinase inhibitor. CAS #: 349087-34-9. Molecular Formula: C21H25NO2S. Molecular Weight: 355.5 g/mol.
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