JX 401

p38 MAP kinase inhibitor

Catalog No. SIH-454

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CAS No. 349087-34-9
Molecular Formula C21H25NO2S
SKU: SIH-454 Categories: ,

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SIH-454_JX-401_Chemical_Structure.png
Product Name JX 401
Description

p38 MAP kinase inhibitor

Purity >98% (TLC)
CAS No. 349087-34-9
Molecular Formula C21H25NO2S
Molecular Weight 355.5
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (20 mg/ml) or ethanol (10 mg/ml)
Source Synthetic
Appearance Off-white solid
SMILES COC1=C(C=CC(=C1)SC)C(=O)N2CCC(CC2)CC3=CC=CC=C3
InChI InChI=1S/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3
InChIKey OMGLGPKQUFSRNN-UHFFFAOYSA-N
Safety Phrases Classification:
Not a hazardous substance or mixture.

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product JX 401 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-454)

Biological Description

Alternative Names 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 1126109
Scientific Background JX 401 is a potent and reversible inhibitor of p38α mitogen-activated protein kinase (MAPK), a key regulator of inflammatory responses and cellular stress signaling. In neurodegenerative disease research, p38α MAPK is implicated in microglial activation, cytokine production, and neuronal apoptosis. JX 401 is used to investigate the role of p38α in neuroinflammation and neurotoxicity, particularly in models of Alzheimer's disease, Parkinson's disease, and traumatic brain injury. Its cell-permeable nature and specificity make it a valuable tool for dissecting MAPK signaling pathways in the central nervous system.
References 1. Friedmann Y., et al. (2006) Mol. Pharm. 70(4): 1395–1405.

Product Images

<p>Chemical structure of JX 401 (SIH-454), a p38alpha MAP kinase inhibitor. CAS #: 349087-34-9. Molecular Formula: C21H25NO2S. Molecular Weight: 355.5 g/mol.</p>

Chemical structure of JX 401 (SIH-454), a p38alpha MAP kinase inhibitor. CAS #: 349087-34-9. Molecular Formula: C21H25NO2S. Molecular Weight: 355.5 g/mol.

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