Discovery through Partnership | Excellence through Quality
| Product Name | KB-R7943 mesylate |
| Description |
TRPC channel blocker |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 182004-65-5 |
| Molecular Formula | C16H17N3O3S•CH3SO3H |
| Molecular Weight | 427.29 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | CS(=O)(=O)O.C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)[N+](=O)[O-] |
| InChI | InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4) |
| InChIKey | WGIKEBHIKKWJLG-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | KB-R7943 mesylate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-312) |
Biological Description
| Alternative Names | 2-{4-[(4-Nitrobenzyl)oxy]phenyl}ethyl carbamimidothioate methanesulfonate (1:1) |
| Research Areas | Ion Channels, Neuroscience |
| PubChem ID | 9823846 |
| Scientific Background | KB-R7943 mesylate is a potent and selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger, a key regulator of intracellular calcium homeostasis. In neuroscience, it is used to study calcium dynamics in neurons, especially under pathological conditions such as ischemia and excitotoxicity. By inhibiting calcium influx via the exchanger, KB-R7943 may reduce neuronal injury and has been explored for its neuroprotective potential in stroke and neurodegenerative disease models. |
| References |
1. Hoyt K.R., Arden S.R., Aizenman E. and Reynolds I.J. (1998) Mol Pharmacol. 53(4): 742-749. 2. Schroder U.H., Breder J, Sabelhaus C.F., Reymann K.G. (1999) Neuropharm. 38(2): 319-321. 3. Watano T., Harada Y., Harada K., Nishimura N. (1999) Br J Pharmacol. 127(8): 1846-1850. |
Product Images
Chemical structure of KB-R7943 mesylate (SIH-312), a TRPC channel blocker. CAS #: 182004-65-5. Molecular Formula: C16H17N3O3S.CH3SO3H. Molecular Weight: 427.29 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.