Kenpaullone

GSK3Beta,CDK2 and LCK Inhibitor

Catalog No. SIH-598

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CAS No. 142273-20-9
Molecular Formula C16H11BrN2O
SKU: SIH-598 Categories: ,

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SIH-598-Kenpaullone-Chemical-Structure.png
Product Name Kenpaullone
Description

GSK3Beta,CDK2 and LCK Inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 142273-20-9
Molecular Formula C16H11BrN2O
Molecular Weight 327.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (35 mg/ml)
Source Synthetic
Appearance Beige powder
SMILES C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br
InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
InChIKey QQUXFYAWXPMDOE-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Kenpaullone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-598)

Biological Description

Alternative Names 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one; NSC-664704
Research Areas Apoptosis, Cancer, Cdks, Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases
PubChem ID 3820
Scientific Background Kenpaullone is a potent inhibitor of cyclin-dependent kinases (CDKs) such as CDK2 and CDK5, as well as casein kinase 1 (CK1) and glycogen synthase kinase 3 beta (GSK3β). These kinases are involved in cell cycle regulation, apoptosis, and tau phosphorylation. In neurodegenerative disease research, Kenpaullone is studied for its ability to inhibit aberrant kinase activity associated with Alzheimer’s disease and other tauopathies. By modulating key signaling pathways, Kenpaullone may help prevent neuronal death and protein aggregation, offering potential neuroprotective benefits.
References 1. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/kenpaullone

Product Images

<p>Chemical structure of Kenpaullone (SIH-598), a GSK3Beta,CDK2 and LCK Inhibitor. CAS #: 142273-20-9. Molecular Formula: C16H11BrN2O. Molecular Weight: 327.2 g/mol.</p>

Chemical structure of Kenpaullone (SIH-598), a GSK3Beta,CDK2 and LCK Inhibitor. CAS #: 142273-20-9. Molecular Formula: C16H11BrN2O. Molecular Weight: 327.2 g/mol.

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