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| Product Name | Kenpaullone |
| Description |
GSK3Beta,CDK2 and LCK Inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 142273-20-9 |
| Molecular Formula | C16H11BrN2O |
| Molecular Weight | 327.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (35 mg/ml) |
| Source | Synthetic |
| Appearance | Beige powder |
| SMILES | C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br |
| InChI | InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) |
| InChIKey | QQUXFYAWXPMDOE-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Kenpaullone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-598) |
Biological Description
| Alternative Names | 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one; NSC-664704 |
| Research Areas | Apoptosis, Cancer, Cdks, Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases |
| PubChem ID | 3820 |
| Scientific Background | Kenpaullone is a potent inhibitor of CK1 and CDK2, and slightly less on CDK5, by competitive inhibition of adenosine triphosphate (ATP) binding. It is also useful as an inhibitor of GSK3Beta. |
| References | 1. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/kenpaullone |
Product Images
Chemical structure of Kenpaullone (SIH-598), a GSK3Beta,CDK2 and LCK Inhibitor. CAS #: 142273-20-9. Molecular Formula: C16H11BrN2O. Molecular Weight: 327.2 g/mol.
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