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| Product Name | MG-132 |
| Description |
Proteasome Inhibitor |
| Purity | >98% |
| CAS No. | 133407-82-6 |
| Molecular Formula | C26H41N3O5 |
| Molecular Weight | 475.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 45 mg/ml DMSO, DMF and ethanol |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1 |
| InChI | InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0 |
| InChIKey | TZYWCYJVHRLUCT-VABKMULXSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | MG-132 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-326) |
Biological Description
| Alternative Names | N-[(Benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxo-2-pentanyl]-L-leucinamide, Z-Leu-Leu-Leu-al, Z-LLL-CHO, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
| Research Areas | Cancer, Heat Shock |
| PubChem ID | 462382 |
| Scientific Background | MG-132 is a specific inhibitor of the 20S proteasome, blocking NF-κB activation by preventing IκB proteolysis. It stimulates autophagy and induces the heat shock response, making it a valuable tool in studying protein degradation and stress pathways. In neuroscience, MG-132 is used to investigate proteostasis, neuroinflammation, and the role of ubiquitin-proteasome system dysfunction in neurodegenerative diseases. |
| References |
1. Tsubuki S., et al. (1996) J. Biochem. 119:572. 2. Wu W.K., et al. (2010) Autophagy 6:228. 3. Meriin A.B., et al. (1998) J. Biol. Chem. 273:6373. |
Product Images
Chemical structure of MG-132 (SIH-326), a Proteasome Inhibitor. CAS #: 133407-82-6. Molecular Formula: C26H41N3O6. Molecular Weight: 476.6 g/mol.
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