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| Product Name | Nelfinavir mesylate |
| Description |
Potent HIV-1 protease inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 159989-65-8 |
| Molecular Formula | C32H45N3O4S • CH3SO3H |
| Molecular Weight | 663.9 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (70 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | [H][C@]12CCCC[C@]([H])1C[C@@H]([C@@](NC(C)(C)C)=O)N(C[C@@H](O)[C@H](CSC3=CC=CC=C3)NC(C4=C(C)C(O)=CC=C4)=O)C2.CS(=O)(O)=O |
| InChI | InChI=1S/C32H45N3O4S.CH4O3S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4;1-5(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8 |
| InChIKey | NQHXCOAXSHGTIA-SKXNDZRYSA-N |
| Safety Phrases | Hazard Statement: H413 May cause long lasting harmful effects to aquatic life. |
| Cite This Product | Nelfinavir mesylate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-586) |
Biological Description
| Alternative Names | (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate; AG-1343 |
| Research Areas | Apoptosis, Autophagy, Cancer |
| PubChem ID | 64142 |
| Scientific Background | Besides being a protease inhibitor used in the therapeutic agent for acquired immunodeficiency syndrome (AIDS), it is also stimulates autophagy and and exhibits anti-cancer properties. It appears to do by inhibition of the Akt/PKB signaling pathway and activation of endoplasmic reticulum stress with subsequent unfolded protein response (1). Nelfinavir has also been shown to treat SARS-coronavirus (2), and is being tested currently to treat COVID-19. |
| References | 1. Koltai T., (2015). F1000Res. 4(2): 9. 2. Yamamoto N., et al. (2004) Biochem Biophys Research Comm. 318: 719-725. |
Product Images
Chemical structure of Nelfinavir mesylate (SIH-586), a HIV-1 protease inhibitor. CAS #: 159989-65-8. Molecular Formula: C32H45N3O4S • CH3SO3H. Molecular Weight: 663.9 g/mol.
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