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| Product Name | Nicardipine HCl |
| Description |
L-type Ca channel blocker |
| Purity | >98% |
| CAS No. | 54527-84-3 |
| Molecular Formula | C26H29N3O6•HCl |
| Molecular Weight | 515.99 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (1 mg/ml), ethanol:water 25:75-70:30, propylene glycol, or methanol; slightly soluble in acetone, 100% ethanol, chloroform and water. |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC.Cl |
| InChI | InChI=1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H |
| InChIKey | AIKVCUNQWYTVTO-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45- In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) Risk Phrases: R23/24/25- Toxic by inhalation, if swallowed and in contact with skin. Hazard Phrases: H301-H311-H331 Precautionary Phrases: P261-P280-P301 + P310-P311 |
| Cite This Product | Nicardipine HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-313) |
Biological Description
| Alternative Names | 2-[Benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1) |
| Research Areas | Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels |
| PubChem ID | 41114 |
| Scientific Background | Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hyptertension and Raynaud’s phenomenon. Its mechanism of acion is to inhibit the transmembrane influx of calcium ions into the cardiac muscle and smooth muscle without changing the serum calcium concentrations. |
| References | 1. Huang R.I., et al. (2006) Catheter Cardiovasc Interv. 68(5): 671-676. |
Product Images
Chemical structure of Nicardipine HCl (SIH-313), a L-type Ca channel blocker. CAS #: 54527-84-3. Molecular Formula: C26H29N3O6 · HCl. Molecular Weight: 515.99 g/mol.
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