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| Product Name | Nonactin |
| Description |
Ammonium ionophore |
| Purity | >98% (TLC) |
| CAS No. | 6833-84-7 |
| Molecular Formula | C40H64O12 |
| Molecular Weight | 736.93 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO, methanol, ethanol (10 mM), dichloromethane and ethyl acetate. Insoluble in water. |
| Source | Synthetic |
| Appearance | White to off-White solid |
| SMILES | C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C |
| InChI | InChI=1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1- |
| InChIKey | RMIXHJPMNBXMBU-QIIXEHPYSA-N |
| Safety Phrases |
Classification: Toxic. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H301+ H311 +H331 – Toxic if swallowed, in contact with skin or inhaled H315 - Causes skin irritation. H319 - Causes serious eye irritation. H335 - May cause respiratory irritation. Precautionary Phrases: P261 - Avoid breathing dust/fume/gas/mist/vapours/spray. P280 - Wear protective gloves/protective clothing. P305+P351+P338 – IF IN EYES: rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P405 – Store locked up. P501 – Dispose of contents/container in accordance with local/regional/national/international regulations. |
| Cite This Product | Nonactin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-372) |
Biological Description
| Alternative Names | (1R,2R,5R,7R,10S,11S,14S,16S,19R,20¬R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-O¬ctamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo-[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,3¬0-tetrone |
| Research Areas | Neuroscience |
| PubChem ID | 72519 |
| Scientific Background | Nonactin, also known as Polynactin or Werramycin A, is a cyclic ionophore with high selectivity for ammonium and potassium ions. While primarily studied for its antimicrobial properties against gram-positive bacteria, its ion transport capabilities have implications in neuroscience. Ionophores like Nonactin can influence neuronal excitability and mitochondrial function, both of which are critical in neurodegenerative disease mechanisms. Although not widely cited in neurodegeneration, its utility in studying ion homeostasis and membrane potential dynamics makes it a valuable compound in neurophysiological research. |
| References |
1. Corbaz R., et al. (1955) Helvetica Chimica Acta 38(60): 1445-48. 2. Kushe B., Smith A., McGuirl M., Priestley N., (2009) J Am Chem Soc 131(47): 17555-165. |
Product Images
Chemical structure of Nonactin (SIH-372), a Ammonium ionophore. CAS #: 6833-84-7. Molecular Formula: C40H64O12. Molecular Weight: 736.93 g/mol.
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