Ponatinib

Tyrosine Kinase Inhibitors

Catalog No. SIH-588

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CAS No. 943319-70-8
Molecular Formula C29H27F3N6O
SKU: SIH-588 Categories: ,

SIH-588-Ponatinib-Chemical-Structure.png
Product Name Ponatinib
Description

Tyrosine Kinase Inhibitors

Purity >98% (HPLC); NMR (conforms)
CAS No. 943319-70-8
Molecular Formula C29H27F3N6O
Molecular Weight 532.6
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (50 mg/ml); or Ethanol (25 mg/ml, warm)
Source Synthetic
Appearance Yellow powder
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
InChIKey PHXJVRSECIGDHY-UHFFFAOYSA-N
Safety Phrases May be harmful by inhalation, ingestion, or skin absorption.
May cause eye, skin, or respiratory system irritation.
Cite This Product Ponatinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-588)

Biological Description

Alternative Names 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide, AP-24534
Research Areas Cancer, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
PubChem ID 24826799
Scientific Background Ponatinib is a multi-targeted tyrosine kinase inhibitor developed for resistant forms of leukemia. It inhibits BCR-ABL as well as kinases associated with VEGFR and FGFR signaling.

Although not traditionally associated with neuroscience, Ponatinib’s inhibition of angiogenic and growth factor pathways has potential implications in brain tumor research and neurovascular disorders. Its ability to cross-inhibit multiple signaling cascades may also be relevant in neurodegenerative diseases where aberrant kinase activity contributes to neuronal dysfunction or glial proliferation.

Product Images

<p>Chemical structure of Ponatinib (SIH-588), a Tyrosine Kinase Inhibitors. CAS #: 943319-70-8. Molecular Formula: C29H27F3N6O. Molecular Weight: 532.6 g/mol.</p>

Chemical structure of Ponatinib (SIH-588), a Tyrosine Kinase Inhibitors. CAS #: 943319-70-8. Molecular Formula: C29H27F3N6O. Molecular Weight: 532.6 g/mol.

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