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| Product Name | Ponatinib |
| Description |
Tyrosine Kinase Inhibitors |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 943319-70-8 |
| Molecular Formula | C29H27F3N6O |
| Molecular Weight | 532.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (50 mg/ml); or Ethanol (25 mg/ml, warm) |
| Source | Synthetic |
| Appearance | Yellow powder |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5 |
| InChI | InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39) |
| InChIKey | PHXJVRSECIGDHY-UHFFFAOYSA-N |
| Safety Phrases |
May be harmful by inhalation, ingestion, or skin absorption. May cause eye, skin, or respiratory system irritation. |
| Cite This Product | Ponatinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-588) |
Biological Description
| Alternative Names | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide, AP-24534 |
| Research Areas | Cancer, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors |
| PubChem ID | 24826799 |
| Scientific Background | Ponatinib is a multi-targeted tyrosine kinase inhibitor. This agent also inhibits other tyrosine kinases including those associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs). |
Product Images
Chemical structure of Ponatinib (SIH-588), a Tyrosine Kinase Inhibitors. CAS #: 943319-70-8. Molecular Formula: C29H27F3N6O. Molecular Weight: 532.6 g/mol.
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