Rapamycin

Name: Rapamycin
SKU: SIH-212
Availability: InStock

mTOR inhibitor

Catalog No. SIH-212

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CAS No.	53123-88-9
Molecular Formula	C51H79NO13

SKU: SIH-212 Categories: Inhibitor, Small Molecules

Product Name	Rapamycin
Description	mTOR inhibitor
Purity	>98%
CAS No.	53123-88-9
Molecular Formula	C₅₁H₇₉NO₁₃
Molecular Weight	914.18
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble to 100 mM in ethanol, and to 50 mM in DMSO
Source	Synthetic
Appearance	White Solid
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
InChI	InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-
InChIKey	QFJCIRLUMZQUOT-HPLJOQBZSA-N
Safety Phrases	Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R68- Possible risk of irreversible effect
Cite This Product	Rapamycin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-212)

Alternative Names	(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-{1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-2-propanyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatr icyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene2,3,10,14,20-pentone
Research Areas	Apoptosis, Cancer, Cancer Growth Inhibitors, mTOR Inhibitors
PubChem ID	5284616
Scientific Background	Rapamycin (Sirolimus) is an immunosuppressant that inhibits the mTOR pathway by binding FKBP12. In neurodegenerative disease research, rapamycin is explored for its ability to modulate autophagy, reduce protein aggregation, and improve cognitive function. It holds promise in the treatment of Alzheimer’s disease, autism, and other neurodevelopmental disorders.
References	1. Gruppuso P.A., Boylan J.M., and Sanders J.A. (2011) Cell Cycle. 10(7): EPub. 2. Ehninger D., et al. (2008) Nat. Med. 14(8): 843-848. 3. Donia M., McCubrey J.A., Bendtzen K., and Nicoletti F. (2010) Br J Clin Pharmacol. 70(6): 784-793.

Chemical structure of Rapamycin (SIH-212), a mTOR inhibitor. CAS #: 53123-88-9. Molecular Formula: C51H79NO13 . Molecular Weight: 914.18 g/mol.

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