Vorinostat (SAHA)

HDAC inhibitor

Catalog No. SIH-359

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CAS No. 149647-78-9
Molecular Formula C14H20N2O3
SKU: SIH-359 Categories: ,

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SIH-359_SAHA_Vorinostat_Chemical_Structure.png
Product Name Vorinostat (SAHA)
Description

HDAC inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 149647-78-9
Molecular Formula C14H20N2O3
Molecular Weight 264.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 50 mg/ml DMSO, or 2 mg/ml Ethanol
Source Synthetic
Appearance White Solid
SMILES C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
InChIKey WAEXFXRVDQXREF-UHFFFAOYSA-N
Safety Phrases Classification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H341-H360 (Suspected of causing genetic defects)
Precautionary Statements:
P201-P281-P308 + P313
Cite This Product SAHA (Vorinostat) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-359)

Biological Description

Alternative Names Suberoylanilide-hydroxamic acid; Vorinostat; N-Hydroxy-N'-phenyloctanediamide
Research Areas Cancer, Cell Signaling
PubChem ID 5311
Scientific Background SAHA (Vorinostat) is a potent, cell-permeable HDAC inhibitor with significant implications in neurodegenerative disease research and neuro-oncology. By altering chromatin structure and gene expression, SAHA promotes neuronal differentiation, reduces neuroinflammation, and enhances synaptic function.

Its ability to synergize with kinase inhibitors to target CNS tumors also positions it as a promising agent in glioblastoma therapy. Widely cited in oncology for its pro-apoptotic effects, SAHA is increasingly recognized in neuroscience for its role in epigenetic modulation and neuroprotection, making it a valuable compound in translational research.
References 1. Vrana J.A., et al., (1999) Oncogene. 18: 7016.
2. Butler L.M., et al., (2002) Proc. Natl. Acad. Sci. USA. 99: 11700.
3. Tang Y., et al., (2012) Cancer Biol. Ther. 2012 13(7): 567-574.

Product Images

<p>Chemical structure of SAHA (Vorinostat) (SIH-359), a HDAC inhibitor. CAS #: 149647-78-9. Molecular Formula: C14H20N2O3. Molecular Weight: 264.3 g/mol.</p>

Chemical structure of SAHA (Vorinostat) (SIH-359), a HDAC inhibitor. CAS #: 149647-78-9. Molecular Formula: C14H20N2O3. Molecular Weight: 264.3 g/mol.

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