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| Product Name | SKF-96365 |
| Description |
TRPC channel blocker |
| Purity | >98% |
| CAS No. | 130495-35-1 |
| Molecular Formula | C22H26N2O3.HCl |
| Molecular Weight | 402.92 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in water |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | COC1=CC=C(C=C1)CCCOC(CN2C=CN=C2)C3=CC=C(C=C3)OC.Cl |
| InChI | InChI=1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4 |
| InChIKey | FWLPKVQUECFKSW-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Irritant. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338 |
| Cite This Product | SKF-96365 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-305) |
Biological Description
| Alternative Names | 1-{2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl}-1H-imidazole hydrochloride (1:1) |
| Research Areas | Ion Channels, Neuroscience |
| PubChem ID | 104956 |
| Scientific Background | SKF-96365 is a selective inhibitor of receptor-mediated and voltage-gated calcium entry. It also inhibits cytochrome P450-mediated reactions and can reversibly activate non-selective cation channels in endothelial cells. In neuroscience, SKF-96365 is used to explore calcium signaling, neurovascular coupling, and the regulation of intracellular calcium dynamics in neurons and glial cells. |
| References |
1. Leis H.J., et al. (1995) Br J Pharmacol. 114(3): 598-601. 2. Sheets J.J., Mason J.I., Wise C.A. and Eastabrook R.W. (1986) Biochem Pharmacol. 35: 487-491. 3. Schwarz G., Droogmans G. and Nilius B. (1994) Cell Calcium. 15: 45-54. |
Product Images
Chemical structure of SKF-96365 (SIH-305), a TRPC channel blocker. CAS #: 130495-35-1. Molecular Formula: C22H26N2O3.HCl. Molecular Weight: 402.92 g/mol.
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