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| Product Name | Stattic |
| Description |
STAT3 inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 19983-44-9 |
| Molecular Formula | C8H5NO4S |
| Molecular Weight | 211.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Blue Ice or 4ºC |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (10 mg/ml); or ethanol (1 mg/ml) |
| Source | Synthetic |
| Appearance | Light yellow powder |
| SMILES | C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-] |
| InChI | InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H |
| InChIKey | ZRRGOUHITGRLBA-UHFFFAOYSA-N |
| Safety Phrases |
WHMIS Classification: D2B - Toxic Material Causing Other Toxic Effects. Moderate skin irritant. Moderate respiratory irritant. Moderate eye irritant GHS Classification: Acute toxicity, Oral (Category 4) Skin irritation (Category 2) Eye irritation (Category 2A) Specific target organ toxicity - single exposure (Category 3) Signal word: Warning Hazard statement(s): H302 Harmful if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s): P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P301 + P312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312 Call a POISON CENTER/doctor if you feel unwell. P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Stattic (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-554) |
Biological Description
| Alternative Names | Stattic, 6-nitro-1-benzothiophene 1,1-dioxide, 6-Nitrobenzo[b]thiophene 1,1-dioxide, Stat three inhibitory compound, STAT3 Inhibitor V, Stattic |
| Research Areas | Alzheimer's Disease, Cancer, Cell Signaling, DNA Synthesis, DNA/RNA, Neurodegeneration, Neuroscience, Stem Cells, Transcription, Transcription Factors |
| PubChem ID | 2779853 |
| Scientific Background | Stattic is a non-peptidic small molecule inhibitor of the STAT3 signaling pathway. In neuroscience, STAT3 is implicated in neuroinflammation, gliosis, and neuronal survival. Stattic inhibits STAT3 dimerization and DNA binding, thereby modulating transcriptional responses to cytokines and growth factors. This makes it a useful tool in neurodegenerative disease research, particularly in models of multiple sclerosis, stroke, and traumatic brain injury. By targeting STAT3, Stattic helps elucidate the role of JAK/STAT signaling in neural repair and inflammation. |
Product Images
Chemical structure of Stattic (SIH-554), a STAT3 inhibitor. CAS #: 19983-44-9. Molecular Formula: C8H5NO4S. Molecular Weight: 211.2 g/mol.
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