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| Product Name | TG003 |
| Description |
Clk family kinase inhibitor |
| Purity | >98% |
| CAS No. | 719277-26-6 |
| Molecular Formula | C13H15NO2S |
| Molecular Weight | 249.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO and to 75 mM in ethanol |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CCN1C2=C(C=CC(=C2)OC)S/C1=CC(=O)C |
| InChI | InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7- |
| InChIKey | BGVLELSCIHASRV-QPEQYQDCSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | TG003 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-515) |
Biological Description
| Alternative Names | TG 003, (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 1893668 |
| Scientific Background | TG003 is a potent inhibitor of CDC-like kinases (Clk), which regulate alternative splicing through phosphorylation of serine/arginine-rich proteins. In neuroscience, TG003 is valuable for studying RNA splicing mechanisms implicated in neurodegenerative diseases such as ALS and frontotemporal dementia. By modulating splicing factor activity, TG003 offers insights into the regulation of neuronal gene expression and the development of therapeutic strategies targeting splicing dysregulation in neurodegeneration. |
| References | 1. Muraki M., et al. (2004) J. Biol. Chem. 279(23): 24246–24254. |
Product Images
Chemical structure of TG003 (SIH-515), a Clk family kinase inhibitor. CAS #: 719277-26-6. Molecular Formula: C13H15NO2S. Molecular Weight: 249.3 g/mol.
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