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| Product Name | Verapamil HCl |
| Description |
L-type Ca channel blocker |
| Purity | >98% |
| CAS No. | 152-11-4 |
| Molecular Formula | C27H38N2O4•HCl |
| Molecular Weight | 491.07 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in ethanol and to 50 mM in water |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl |
| InChI | InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18, |
| InChIKey | DOQPXTMNIUCOSY-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible) Risk Phrases: R23/24/25 - Toxic by inhilation, in contact with skin and if swallowed R60 - May impair fertility R61 - May cause harm to the unborn child R68 - Possible risk of irreversible effects Hazard Phrases: H301-H311-H331 Precautionary Phrases: P261-P280-P301 + P310-P311 |
| Cite This Product | Verapamil HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-308) |
Biological Description
| Alternative Names | 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile hydrochloride (1:1) |
| Research Areas | Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels |
| PubChem ID | 62969 |
| Scientific Background | Verapamil HCl is a phenylalkylamine-class L-type calcium channel blocker widely used in cardiovascular medicine. In neuroscience, its ability to inhibit voltage-dependent calcium channels has made it a valuable tool for studying calcium signaling in neurons. Verapamil has been investigated for its neuroprotective effects, particularly in models of excitotoxicity and neurodegeneration where calcium dysregulation plays a central role. Its modulation of intracellular calcium levels may influence synaptic transmission, neuronal excitability, and apoptotic pathways, making it relevant in research on stroke, epilepsy, and neurodegenerative diseases. |
| References | 1. Livesley B., and Oram S. (1972) Br Med J. 2(5804): 50. |
Product Images
Chemical structure of Verapamil HCl (SIH-308), a L-type Ca channel blocker. CAS #: 152-11-4. Molecular Formula: C27H38N2O4.HCl. Molecular Weight: 491.07 g/mol.
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