Verapamil HCl

L-type Ca channel blocker

Catalog No. SIH-308

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CAS No. 152-11-4
Molecular Formula C27H38N2O4•HCl
SKU: SIH-308 Categories: ,

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SIH-308_Verapamil_HCl_Chemical_Structure.png
Product Name Verapamil HCl
Description

L-type Ca channel blocker

Purity >98%
CAS No. 152-11-4
Molecular Formula C27H38N2O4•HCl
Molecular Weight 491.07
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in ethanol and to 50 mM in water
Source Synthetic
Appearance White Solid
SMILES CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl
InChI InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,
InChIKey DOQPXTMNIUCOSY-UHFFFAOYSA-N
Safety Phrases Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
R23/24/25 - Toxic by inhilation, in contact with skin and if swallowed
R60 - May impair fertility
R61 - May cause harm to the unborn child
R68 - Possible risk of irreversible effects
Hazard Phrases:
H301-H311-H331
Precautionary Phrases:
P261-P280-P301 + P310-P311
Cite This Product Verapamil HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-308)

Biological Description

Alternative Names 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile hydrochloride (1:1)
Research Areas Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels
PubChem ID 62969
Scientific Background Verapamil HCl is a phenylalkylamine-class L-type calcium channel blocker widely used in cardiovascular medicine. In neuroscience, its ability to inhibit voltage-dependent calcium channels has made it a valuable tool for studying calcium signaling in neurons. Verapamil has been investigated for its neuroprotective effects, particularly in models of excitotoxicity and neurodegeneration where calcium dysregulation plays a central role. Its modulation of intracellular calcium levels may influence synaptic transmission, neuronal excitability, and apoptotic pathways, making it relevant in research on stroke, epilepsy, and neurodegenerative diseases.
References 1. Livesley B., and Oram S. (1972) Br Med J. 2(5804): 50.

Product Images

<p>Chemical structure of Verapamil HCl (SIH-308), a L-type Ca channel blocker. CAS #: 152-11-4. Molecular Formula: C27H38N2O4.HCl. Molecular Weight: 491.07 g/mol.</p>

Chemical structure of Verapamil HCl (SIH-308), a L-type Ca channel blocker. CAS #: 152-11-4. Molecular Formula: C27H38N2O4.HCl. Molecular Weight: 491.07 g/mol.

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