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| Product Name | Vildagliptin |
| Description |
Anti-diabetic agent |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 274901-16-5 |
| Molecular Formula | C17H25N3O2 |
| Molecular Weight | 303.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | C1C[C@@H](C#N)N(C1)C(=O)CN[C@]12C[C@@H]3C[C@H](C1)C[C@@](C3)(C2)O |
| InChI | InChI=1S/C17H25N3O2/c18-9-14-2-1-3-20(14)15(21)10-19-16-5-12-4-13(6-16)8-17(22,7-12)11-16/h12-14,19,22H,1-8,10-11H2/t12-,13+,14-,16+,17-/m0/s1 |
| InChIKey | SYOKIDBDQMKNDQ-NHMCJKAESA-N |
| Safety Phrases |
Signal Word: Warning GHS Classifcation: GHS07 Acute toxicity (oral, dermal, inhalation), category 4 Skin irritation, category 2 Eye irritation, category 2 Skin sensitisation, category 1 Specific Target Organ Toxicity – Single exposure, category 3 Hazard statement(s): H302 H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s): P301 + P312 + P330-P305 + P351 + P338 |
| Cite This Product | Vildagliptin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-567) |
Biological Description
| Alternative Names | (S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile; LAF237 |
| Research Areas | Alzheimer's Disease, Atherosclerosis, Cardiovascular System, Diabetes Associated, Neurodegeneration, Neuroscience |
| PubChem ID | 11077541 |
| Scientific Background | Vildagliptin is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV), an enzyme responsible for degrading glucagon-like peptide-1 (GLP-1). By delaying GLP-1 degradation, Vildagliptin enhances insulin secretion and suppresses glucagon release, thereby improving glycemic control. In neurodegenerative disease research, Vildagliptin has shown promise in ameliorating cognitive deficits in models of Alzheimer’s disease. It also exhibits protective effects on pancreatic β-cells by reducing endoplasmic reticulum stress. These neuroprotective and anti-inflammatory properties make Vildagliptin a candidate for exploring the metabolic-neurodegenerative interface, particularly in diabetes-associated cognitive decline. |
| References |
1. B Balas et al., (2007) J. Clin. Endocrinol. Metab. 92:1249. 2. B Ahren et al., (2004) J. Clin. Endocrinol. Metab. 89:2078. |
Product Images
Chemical structure of Vildagliptin (SIH-567), a Antidiabetic Agent. CAS #: 274901-16-5 . Molecular Formula: C17H25N3O2. Molecular Weight: 303.4 g/mol.
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