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| Product Name | Wortmannin |
| Description |
Autophagy inhibitor |
| Purity | >98% |
| CAS No. | 19545-26-7 |
| Molecular Formula | C23H24O8 |
| Molecular Weight | 428.44 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (50 mg/ml), methanol (5 mg/ml) or 100% ethanol (25 mg/ml). |
| Source | Synthetic |
| Appearance | White to off-white solid. |
| SMILES | [C@@]15(C4=C(C(C2=C1[C@@H](C[C@]3([C@H]2CCC3=O)C)OC(=O)C)=O)OC=C4C(O[C@@H]5COC)=O)C |
| InChI | InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 |
| InChIKey | QDLHCMPXEPAAMD-QAIWCSMKSA-N |
| Safety Phrases |
Classification: D1A- Very Toxic Material Causing Immediate and Serious Toxic Effects, Highly toxic by ingestion, Highly toxic by skin absorption Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H300 + H310- Fatal if swallowed or in contact with skin H330- Fatal if inhaled. Precautionary statements: P260- Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P264- Wash hands thoroughly after handling. P280- Wear protective gloves/ protective clothing. P284- Wear respiratory protection. P302 + P350- IF ON SKIN: Gently wash with plenty of soap and water. P310- Immediately call a POISON CENTER or doctor/ physician. |
| Cite This Product | Wortmannin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-392) |
Biological Description
| Alternative Names | SL-2052, KY12420 |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 312145 |
| Scientific Background | Wortmannin is a fungal metabolite that irreversibly inhibits phosphatidylinositol 3-kinase (PI3K), a key regulator of intracellular signaling pathways involved in growth, metabolism, and autophagy. In neuroscience, Wortmannin is used to investigate the PI3K/Akt/mTOR pathway, which plays a central role in neuronal survival, synaptic plasticity, and neuroinflammation. By inhibiting PI3K, Wortmannin suppresses autophagy and disrupts membrane trafficking—processes essential for neuronal maintenance and function. Its application in neurodegenerative disease models helps elucidate the impact of impaired PI3K signaling on protein aggregation, mitochondrial dysfunction, and cell death. Wortmannin is also used to study insulin signaling in the brain, relevant to Alzheimer’s disease and metabolic-cognitive disorders. |
| References |
1. Powis G., et al. (1994). Cancer Res. 54(9): 2419-23. 2. Hazeki O., et al. (1996). J Lipid Mediat Cell Signal. 14(1-3): 259-61. 3. Lee A., et al. (1995). FEBS Lett. 361(1): 51-4. 4. Blommaart E. F., et al. (1997). Eur J Biochem. 243(1-2): 240-6. |
Product Images
Chemical structure of Wortmannin (SIH-392), a Autophagy inhibitor. CAS #: 19545-26-7. Molecular Formula: C23H24O8. Molecular Weight: 428.44 g/mol.
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