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| Product Name | Y 27632 |
| Description |
ROCK kinase inhibitor |
| Purity | >98% (HPLC) |
| CAS No. | 146986-50-7 |
| Molecular Formula | C14H23Cl2N3O |
| Molecular Weight | 320.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (25 mg/ml), methanol (25 mg/ml), acetonitrile (<1 mg/ml), dioxan (<1 mg/ml), water (very soluble |
| Source | Synthetic |
| Appearance | White to pale yellow powder |
| SMILES | C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)NC2=CC=NC=C2.Cl.Cl |
| InChI | InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11?,12?/m1/s1 |
| InChIKey | IYOZTVGMEWJPKR-VOMCLLRMSA-N |
| Safety Phrases |
Classification: Acute toxicity, Oral (Category 4), H302 Acute toxicity, Inhalation (Category 4), H332 Acute toxicity, Dermal (Category 4), H312 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ protective clothing. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P322 Specific measures (see supplemental first aid instructions on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Y 27632 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-486) |
Biological Description
| Alternative Names | Y-27632 dihydrochloride, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide . 2HCl |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 448042 |
| Scientific Background | Y 27632 is a highly potent and selective inhibitor of Rho-associated protein kinases ROCK1 and ROCK2. It functions as an ATP-competitive inhibitor and is cell-permeable. In neurodegenerative disease research, Y 27632 is widely used to study cytoskeletal dynamics, axonal regeneration, and neuronal survival. By inhibiting ROCK signaling, Y 27632 promotes neurite outgrowth and reduces apoptosis, making it a promising compound for therapeutic strategies targeting spinal cord injury, Parkinson’s disease, and other neurodegenerative conditions. |
| References | 1. Shi J., et al. (2013) Cell Death & Disease, 4: e483. |
Product Images
Chemical structure of Y 27632 (SIH-486), a ROCK family kinase inhibitor. CAS #: 146986-50-7. Molecular Formula: C14H23Cl2N3O. Molecular Weight: 320.3 g/mol.
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