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| Product Name | Z-VAD-FMK |
| Description |
Pan-specific caspase inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 187389-52-2 |
| Molecular Formula | C22H30FN3O7 |
| Molecular Weight | 467.49 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Blue Ice or 4ºC |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (10 mg/ml) |
| Source | Synthetic |
| Appearance | Lyophilized solid or wax |
| SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1 |
| InChI | InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1 |
| InChIKey | MIFGOLAMNLSLGH-QOKNQOGYSA-N |
| Safety Phrases |
This product does not require a Material Safety Data Sheet under the Occupational Safety and Health Administration standard entitled "Hazard Communication" 29 CFR 1910.1200 for the United States. The product does not meet the criteria of W.H.M.I.S. classification as a controlled product. As a result, a W.H.M.I.S. Material Safety Data Sheet is not required (in Canada) for this product. |
| Cite This Product | Z-VAD-FMK (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-557) |
Biological Description
| Alternative Names | ZVAD-FMK, Z-VAD-FMK, Caspase Inhibitor I, Z-VAD (OMe)-FMK, Z-VAD(OMe)-FMK, Ac-ZVAD-FMK, benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone, carbobenzoxyvalyl-alanyl-aspartyl fluoromethyl ketone, FK 009, FK-009, FK009, Z-VAD.FMK, Z-Val-Ala-Asp-fluoromethylketone, ZVAD-fluoromethylketone, methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoate |
| Research Areas | Alzheimer's Disease, Apoptosis, Cancer, Cardiovascular System, Heart, Neurodegeneration, Neuroscience |
| PubChem ID | 5497174 |
| Scientific Background | Z-VAD-FMK is a broad-spectrum, irreversible pan-caspase inhibitor that blocks apoptosis by inhibiting caspase activation. In neuroscience, it is used to investigate the role of programmed cell death in neurodegenerative diseases, traumatic brain injury, and ischemic stroke. By preventing caspase-mediated neuronal apoptosis, Z-VAD-FMK helps delineate the molecular pathways involved in cell death and survival. It is also employed to study neuroinflammation and glial responses, making it a critical tool for exploring therapeutic interventions aimed at preserving neuronal integrity. |
Product Images
Chemical structure of Z-VAD-FMK (SIH-557), a Pan-specific caspase inhibitor. CAS #: 187389-52-2. Molecular Formula: C22H30FN3O7. Molecular Weight: 467.49 g/mol.
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