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| Product Name | 5-Ethynyl-2’-deoxyuridine |
| Description |
DNA labeling agent |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 61135-33-9 |
| Molecular Formula | C11H12N2O5 |
| Molecular Weight | 252.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Labelling Agent |
| Solubility | May be dissolved in DMSO (10 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | O=C(NC(C(C#C)=C1)=O)N1[C@H]2C[C@H](O)[C@@H](CO)O2 |
| InChI | InChI=1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1 |
| InChIKey | CDEURGJCGCHYFH-DJLDLDEBSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | 5-Ethynyl-2'-deoxyuridine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-597) |
Biological Description
| Alternative Names | 2'-Deoxy-5-ethynyluridine; 5-EdU; 5-Ethynyl-2'-deoxyuridine; EdU |
| Research Areas | Cancer, Cell Signaling, DNA Damage and Repair, DNA/RNA, Epigenetics and Nuclear Signaling, Oxidation, Oxidative Stress, Post-translational Modifications |
| PubChem ID | 472172 |
| Scientific Background | 5-Ethynyl-2’-deoxyuridine (EdU) is a thymidine analog used to label newly synthesized DNA, enabling precise detection of cell proliferation via click chemistry. Unlike traditional methods such as BrdU incorporation, EdU does not require DNA denaturation, preserving cellular integrity and improving detection sensitivity. In neuroscience, EdU is extensively used to monitor neurogenesis, particularly in studies of brain development, injury response, and neurodegenerative disease models. Its compatibility with multiplexed imaging makes it a powerful tool for tracking neural stem cell dynamics and evaluating regenerative therapies. |
| References | 1. Salic A., and Mitchison, T.J. (2008) Proc. Natl. Acad. Sci. USA. 105:2415. |
Product Images
Chemical structure of 5-Ethynyl-2′-deoxyuridine (SIH-597), a DNA Labelling Agent. CAS #: 61135-33-9. Molecular Formula: C11H12N2O5. Molecular Weight: 252.2 g/mol.
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