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| Product Name | Nicardipine HCl |
| Description |
L-type Ca channel blocker |
| Purity | >98% |
| CAS No. | 54527-84-3 |
| Molecular Formula | C26H29N3O6•HCl |
| Molecular Weight | 515.99 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (1 mg/ml), ethanol:water 25:75-70:30, propylene glycol, or methanol; slightly soluble in acetone, 100% ethanol, chloroform and water. |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC.Cl |
| InChI | InChI=1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H |
| InChIKey | AIKVCUNQWYTVTO-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S45- In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) Risk Phrases: R23/24/25- Toxic by inhalation, if swallowed and in contact with skin. Hazard Phrases: H301-H311-H331 Precautionary Phrases: P261-P280-P301 + P310-P311 |
| Cite This Product | Nicardipine HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-313) |
Biological Description
| Alternative Names | 2-[Benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1) |
| Research Areas | Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels |
| PubChem ID | 41114 |
| Scientific Background | Nicardipine HCl is a dihydropyridine calcium channel blocker used to treat vascular disorders. In neuroscience, it is employed to investigate cerebral blood flow regulation and neurovascular coupling. Nicardipine’s inhibition of calcium influx in smooth muscle cells can influence cerebral perfusion and has been studied in models of stroke, traumatic brain injury, and migraine. Its role in modulating neurovascular responses makes it a valuable tool in neuropharmacology. |
| References | 1. Huang R.I., et al. (2006) Catheter Cardiovasc Interv. 68(5): 671-676. |
Product Images
Chemical structure of Nicardipine HCl (SIH-313), a L-type Ca channel blocker. CAS #: 54527-84-3. Molecular Formula: C26H29N3O6 · HCl. Molecular Weight: 515.99 g/mol.
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