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| Product Name | Niclosamide |
| Description |
Autophagy inducer |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 50-65-7 |
| Molecular Formula | C13H8Cl2N2O4 |
| Molecular Weight | 327.12 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 25 mM in ethanol and to 10 mM in DMSO |
| Source | Synthetic |
| Appearance | Pale yellow solid |
| SMILES | C2=C(C(NC1=C(C=C([N+](=O)[O-])C=C1)Cl)=O)C(=CC=C2Cl)O |
| InChI | InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19) |
| InChIKey | RJMUSRYZPJIFPJ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Niclosamide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-406) |
Biological Description
| Alternative Names | 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 4477 |
| Scientific Background | Niclosamide is part of the anthelmintics drug class, which are used to treat tapeworm infections in humans. Niclosamide has been shown to selectively inhibit the Stat-3 signalling pathway, specifically by inhibiting its activation, nuclear translocation and transcriptional activity. It has also been reported that Niclosamide inhibits mTORC1, thereby inducing autophagy and increasing the formation of autophagosomes. |
| References | 1. Pan J.X., et al. (2012) Chin J Cancer. 31(4): 178-84. |
Product Images
Chemical structure of Niclosamide (SIH-406), a Autophagy inducer. CAS #: 50-65-7. Molecular Formula: C13H8Cl2N2O4. Molecular Weight: 327.12 g/mol.
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