Piperlongumine

Apoptosis Inducer

Catalog No. SIH-156

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CAS No. 20069-09-4
Molecular Formula C17H19NO5
SKU: SIH-156 Categories: ,

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SIH-156_Piperlongumine_Chemical_Structure.png
Product Name Piperlongumine
Description

Apoptosis Inducer

Purity >98%
CAS No. 20069-09-4
Molecular Formula C17H19NO5
Molecular Weight 317.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble in 25 mg/ml DMSO
Source Synthetic
Appearance Cream Solid
SMILES COC1=CC(=CC(=C1OC)OC)/C=C/C(=O)N2CCC=CC2=O
InChI InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3
InChIKey VABYUUZNAVQNPG-UHFFFAOYSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Phrases:
H302
Cite This Product Piperlongumine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-156)

Biological Description

Alternative Names 1-[(2E)-3-(3,4,5-Trimethoxyphenyl)-2-propenoyl]-5,6-dihydro-2(1H)-pyridinone
Research Areas Cancer, Oxidative Stress
PubChem ID 637858
Scientific Background Piperlongumine is a novel compound that exhibits a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid and platelet activating factor, without any inhibiting effect on that induced by thrombin (1). It has recently been found to kill cancer cells by blocking the response that dissipates high oxidative stress and the resulting reactive oxygen species (ROS) generated, meanwhile sparing normal cells (2).
References 1. Park B.S., et al. (2008) Phytother Res. 22(9): 1195-1199.
2. Raj L., et al. (2011) Nature. 475(7355): 231.

Product Images

<p>Chemical structure of Piperlongumine (SIH-156), a Apoptosis inducer in oxidative stressed cells. CAS #: 20069-09-4. Molecular Formula: C17H19NO5. Molecular Weight: 317.3 g/mol.</p>

Chemical structure of Piperlongumine (SIH-156), a Apoptosis inducer in oxidative stressed cells. CAS #: 20069-09-4. Molecular Formula: C17H19NO5. Molecular Weight: 317.3 g/mol.

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