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| Product Name | Spautin-1 |
| Description |
Autophagy inhibitor |
| Purity | >98% |
| CAS No. | 1262888-28-7 |
| Molecular Formula | C15H11F2N3 |
| Molecular Weight | 271.26 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (15 mg/ml). |
| Source | Synthetic |
| Appearance | White to beige powder. |
| SMILES | c1cc(ccc1CNc2c3cc(ccc3ncn2)F)F |
| InChI | InChI=1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20) |
| InChIKey | AWIVHRPYFSSVOG-UHFFFAOYSA-N |
| Safety Phrases |
Classification: D2B- Toxic Material Causing Other Toxic Effects, Severe eye irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302- Harmful if swallowed. H318- Causes serious eye damage. Precautionary statements: P280- Wear protective gloves/ eye protection/ face protection. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Cite This Product | Spautin-1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-404) |
Biological Description
| Alternative Names | 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 51037431 |
| Scientific Background | Spautin-1 inhibits the deubiquitination activity of USP10 and USP13, two ubiquitin-specific peptidases. This results in the degradation of class III PI3 kinase complexes. Because this group of kinases regulates autophagy, Spautin-1 in turn inhibits autophagy. |
| References | 1. Liu J., et al. (2011) Cell. 147(1): 223-34. |
Product Images
Chemical structure of Spautin-1 (SIH-404), a Autophagy inhibitor. CAS #: 1262888-28-7. Molecular Formula: C15H11F2N3. Molecular Weight: 271.26 g/mol.
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