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| Product Name | MAPKII Kinase Inhibitor |
| Description |
Hsp25 Kinase Inhibitor |
| Purity | >95% |
| Molecular Formula | C61H113N21O6 |
| Molecular Weight | 1396.7 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO or H20 |
| Source | Synthetic |
| Appearance | White Solid |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | MAPKII Kinase Inhibitor (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-120) |
Biological Description
| Research Areas | Cancer, Heat Shock |
| Scientific Background | The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). In particular, MAPKAP-kinase II (or otherwise known as MK2) is involved in inflammation, and is considered a target for therapeutic intervention for inflammation and cancer (3). MK2 is a member of the p38 MAPKinase pathway, and is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (3). |
| References |
1. Pearson G. et al. (2001). Endocrine Reviews 22 (2): 153-183. 2. Fan Y., et al. (2007) Mol. Cells 23 (1): 30-38. 3. Deng et al. (2003) Cell 115: 61-70. |
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