PK-11195

Mitochondrial Benzodiazepine receptor ligand

Catalog No. SIH-224

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CAS No. 85532-75-8
Molecular Formula C21H21CIN2O
SKU: SIH-224 Categories: ,

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SIH-224_PK-11195_Chemical_Structure.png
Product Name PK-11195
Description

Mitochondrial Benzodiazepine receptor ligand

Purity >98%
CAS No. 85532-75-8
Molecular Formula C21H21CIN2O
Molecular Weight 352.86
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble to 75 mM in ethanol and to 100 mM in DMSO
Source Synthetic
Appearance White Crystals
SMILES CCC(C)N(C)C(=O)C1=CC2=CC=CC=C2C(=N1)C3=CC=CC=C3Cl
InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
InChIKey RAVIZVQZGXBOQO-UHFFFAOYSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22- Harmful by inhalation, in contact with skin and if swallowed
R68- Possible risk of irreversible effects
Cite This Product PK-11195 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-224)

Biological Description

Alternative Names N-sec-Butyl-1-(2-chlorophenyl)-N-methyl-3-isoquinolinecarboxamide
Research Areas Apoptosis, Cancer
PubChem ID 1345
Scientific Background PK-11195 is an isoquinoline carboxamide which binds selectively to the peripheral benzodiazepine receptor (PBR). It has a high affinity for the PBR in all species (1). It has also been successfully used in PET scans to visualize brain inflammation in patients with neuronal damage (2).
References 1. Pike V.W., et al. (1993) Nucl Med & Bio. 20(4): 503-525.
2. Buck J.R., et al. (2011) J Nucl Med. 52(1): 107-114.

Product Images

<p>Chemical structure of PK-11195 (SIH-224), a Mitochondrial benzodiazepine receptor ligand. CAS #: 85532-75-8. Molecular Formula: C21H21CIN2O. Molecular Weight: 352.86 g/mol.</p>

Chemical structure of PK-11195 (SIH-224), a Mitochondrial benzodiazepine receptor ligand. CAS #: 85532-75-8. Molecular Formula: C21H21CIN2O. Molecular Weight: 352.86 g/mol.

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