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| Product Name | 5-Azacytidine |
| Description |
DNA hypomethylation agent |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 320-67-2 |
| Molecular Formula | C8H12N4O5 |
| Molecular Weight | 244.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 25 mg/ml DMSO or 12 mg/ml Water |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N |
| InChI | InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1 |
| InChIKey | NMUSYJAQQFHJEW-KVTDHHQDSA-N |
| Safety Phrases |
Classification: Harmful- May be harmful if inhaled, swallowed, or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302- Harmful if swallowed H350 – May cause cancer Precautionary Statements: P201 – Obtain special instructions before use. P308 + P313 – If exposed or concerned: Get medical advice/attention |
| Cite This Product | 5-Azacytidine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-345) |
Biological Description
| Alternative Names | 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; Ladakamycin; U-18496; NSC-102816; 5-AzaC |
| Research Areas | Cancer, Cell Signaling |
| PubChem ID | 9444 |
| Scientific Background | DNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of silenced genes. Improves the efficiency of reprogramming of stem cells; induces differentiation of mesenchymal stem cells into cardiomyocytes. |
| References |
1. Schneider-Stock R., et al. (2005) J Pharmacol Exp Ther. 312(2): 525-536. 2. Mikkelsen T.S., et al., (2008) Nature. 454(7200): 49-55. 3. Qian Q., et al., (2012) Stem Cells Dev. 21(1): 67-75. |
Product Images
Chemical structure of 5-Azacytidine (SIH-345), a DNA hypomethylation agent. CAS #: 320-67-2. Molecular Formula: C8H12N4O5. Molecular Weight: 244.2 g/mol.
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Based on validation through cited publications.