HSP Modulators: Apoptozole

Apoptozole Chemical Structure HSP70 Inhibitors and ModulatorsApoptozole

Heat Shock Protein 70/HSP70 Inhibitor

CAS Number: 1054543-47-3

Molecular Formula: C33H25F6N3O3

Molecular Weight: 625.57 g/mol

Research Areas: Cancer Research, Heat Shock, Apoptosis


Alternative Names: Apoptosis Activator VII, 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl)methyl)benzamide


Biological Description

Apoptozole binds within Hsp70 nucleotide binding domain. It inhibits Hsp70 ATPase turnover rate. It triggers apoptosis in P19 embryonic carcinoma and A549 lung cancer cultures. The selectivity for Hsp70 is uncertain.


  1. Williams DR, et al. An apoptosis-inducing small molecule that binds to heat shock protein 70. Angew Chem Int Ed Engl. 2008;47(39):7466-9. 
  2. Cho HJ, et al. A Small Molecule That Binds to an ATPase Domain of Hsc70 Promotes Membrane Trafficking of Mutant Cystic Fibrosis Transmembrane Conductance Regulator. J Am Chem Soc. 2011;133(50):20267-76.