Spergualin

Heat Shock Protein 70/HSP70 Inhibitor

Molecular Formula: C₁₇H₃₇N₇O₄

Molecular Weight: 403.53 g/mol

Research Areas: Cancer Research, Heat Shock, Apoptosis, Cell Signalling

 

Alternative Names: 15-deoxyspergualin, (S)-N-((S)-2-((4-((3-aminopropyl)amino)butyl)amino)-1-hydroxy-2-oxoethyl)-7-guanidino-3-hydroxyheptanamide, Antibiotic BMG 162aF2, Heptanamide

Commonly supplied as Spergualin trihydrochloride (CAS No. 80952-47-2).

 

Biological Description

Spergualin is a polyamine antibiotic isolated from Bacillus laterosporus that has been found to have antibacterial, antitumor, and immunosuppressive properties. It binds the C-terminus of Heat shock protein 70 (Hsp70) and 90 (HSP90) and it chemically crosslinks to the “EEVD” motif. Spergualin has shown anticancer activity against transplantable leukemias in mice. It has also been found to be effective in preventing skin graft rejection.

 

References:

1. Nadler SG, et al. Identification of a binding site on Hsc70 for the immunosuppressant 15-deoxyspergualin. Biochem Biophys Res Commun. 1998;253(1):176-80.