HSP Modulators: Pifithrin-mu

Pifithrin-mu Chemical Structure - HSP70 Inhibitors and ModulatorsPifithrin-μ

Heat Shock Protein 70/HSP70 Inhibitor

StressMarq catalog# SIH-325

CAS Number: 64984-31-2

Molecular Formula: C8H7NO2S

Molecular Weight: 181.21 g/mol

Research Areas: Cancer Research, Heat Shock, Apoptosis, Cell Signalling

Alternative Names: Pifithrin-mu, PES, 2-phenylethyne-1-sulfonamide, 2-phenylethynesulfonamide, PFTμ

 

Biological Description

Pifithrin-μ has been found to interact with the Heat shock protein 70 (Hsp70) substrate binding domain. Pifithrin-μ has anti-cancer activities by disrupting protein-protein interactions between Hsp70 and p53. It triggers both apoptosis and autophagy. Currently, a chlorated version of Pifithrin-μ, PES-Cl, has more potent anti-cancer activities. The selectivity for Hsp70 is uncertain.

References:

  1. Leu JI, et al. A small molecule inhibitor of inducible heat shock protein 70. Mol Cell. 2009;36(1):15-27.
  2. Balaburski GM, et al. A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res. 2013;11(3):219-29.