JG-13

Heat Shock Cognate 70/HSC70 Inhibitor

Molecular Formula: C₁₉H₁₆FN₃OS₂

Molecular Weight: 385.48 g/mol

Research Areas: Cancer Research, Heat Shock

Alternative Names: (2Z,5E)-3-ethyl-5-(6-fluoro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-2-(pyridin-4-ylmethylene)thiazolidin-4-one

Biological Description

JG-13 blocks Hsc70-Bag1 interactions in vitro, with IC50 of 10 μM. It reduces both phosphorylated and total tau in tau overexpressed HeLa cells. JG-13 is an active anti-cancer compound, with IC50s in 0.5 – 2 μM against MCF-7 and MDA-MB-231 cells. It is microsomal stable, with half life of 30 min.