HSP Modulators: MAL3-101

MAL3-101 Chemical Structure HSP70 Inhibitors and ModulatorsMAL3-101

Heat Shock Protein 70/HSP70 Inhibitor

CAS Number: 912361-26-3

Molecular Formula: C54H66N4O10

Molecular Weight: 931.14 g/mol

Research Areas: Cancer Research, Heat Shock, Apoptosis


Alternative Names: Benzyl 4-([1,1′-biphenyl]-4-yl)-1-(6-((2-(butylamino)-1-(4-(2-methoxy-2-oxoethoxy)-3-(methoxycarbonyl)phenyl)-2-oxoethyl)(hexyl)amino)-6-oxohexyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate


Biological Description

MAL3-101 is an allosteric Heat shock protein 70 (Hsp70) modulator. It inhibits Hsp70 ATPase activity. MAL3-101 binds within the interface between Hsp70 and Hsp40. It has anti-proliferative activity against multiple myeloma cells. MAL3-101 treatment has been shown to also cause apoptosis in Merkel Cell Carcinomas. It also showed in vivo antitumor activity in an Merkel Cell Carcinomas xenograft model.



  1. Fewell SW, et al. Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity. J Biol Chem. 2004;279(49):51131-40. 
  2. Wisen S, et al. Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. ACS Chem Biol. 2010;5(6):611-22.
  3. Braunstein MJ, et al. Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101. J Oncol. 2011;2011:232037.
  4. Adam C, et al. The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma. PLoS One. 2014;9(4):e92041.