HSP Modulators: VER-155008

VER-155008 Chemical Structure HSP70 Inhibitors and ModulatorsVER-155008

Heat Shock Protein 70/HSP70 Inhibitor

CAS Number: 1134156-31-2

Molecular Formula: C25H23Cl2N7O4

Molecular Weight: 556.4 g/mol

Research Areas: Cancer Research, Heat Shock, Apoptosis, Cell Signalling

Alternative Names: 4-((((2R,5R)-5-(6-amino-8-((3,4-dichlorobenzyl)amino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)benzonitrile, 5′-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine


Biological Description

VER-155008 is an ATP/adenosine analogue and a competitive Heat shock protein 70 (Hsp70) inhibitor with IC50 of 0.5 uM. It destabilizes oncoproteins, including Raf-1, Her-2, in several cancer cell lines. VER-155008 activates caspase-dependent and independent apoptosis in colon cancer cells. Selectivity for Hsp70 is uncertain as it has been found to bind Hsc70, Grp78, and Hsp90β.



  1. Williamson DS, et al. Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design. J Med Chem. 2009;52(6):1510-3.
  2. Massey AJ, et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol. 2010;66(3):535-45.