Products

  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 1)

    Catalog No. SPR-321

    5.00 out of 5 based on 1 customer rating
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    Expression System E. coli
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    SPR-321_Alpha-Synuclein-Protein-Monomer-Thioflavin-T-assay-1.png
    SDS-Page of huma alpha synuclein monomer (SPR-321)

  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 2)

    Catalog No. SPR-316

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    Expression System E. coli
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    SPR-316_Alpha-Synuclein-Protein-Monomer-Protein-SDS-Page-1.png
    Alpha Synuclein monomers (SPR-316) do not form new alpha synuclein fibrils when combined with Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by a limited increase in fluorescence intensity by Thioflavin T over time.Alpha Synuclein Monomer RT-QuiC AssayΑlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.LDH assay shows effect of alpha synuclein monomers on mouse primary neuronsMTT assay shows effects of alpha synuclein monomers on mouse primary neurons

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 2)

    Catalog No. SPR-317

    5.00 out of 5 based on 2 customer ratings
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    Expression System E. coli
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    SPR-317_Alpha-Synuclein-Preformed-Fibrils-Protein-TEM-4.png
    TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-317)Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.SDS-Page of Type 2 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-317)Type 2 alpha synuclein Pre-formed fibrils (SPR-317) do not seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) at the same rate as Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by lower fluorescence intensity values of Thioflavin T over time.Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)LDH assay shows effect of alpha synuclein PFFs on mouse primary neuronsMTT assay effects of alpha synuclein PFFs on mouse primary neurons

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 1)

    Catalog No. SPR-322

    5.00 out of 5 based on 1 customer rating
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    Expression System E. coli
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    SPR-322_Alpha-Synuclein-Protein-Preformed-Fibrils-Protein-TEM-7.png
    Αlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)StressMarq’s Alpha Synuclein PFFs (red) cat#SPR-322, were shown to be taken up by SH-SY5Y cells and transmitted to neuronal iPSCs within 14 days.SDS-Page of Type 1 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-322)Type 1 alpha synuclein Pre-formed fibrils (SPR-322) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) as shown by increased fluorescence intensity by Thioflavin T over time.Immunocytochemistry/Immunofluorescence of Human Alpha Synuclein Protein Protein (SPR-322)Mouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFsMouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFs cause endogenous alpha synuclein phosphorylationTEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-322)IHC of Sprague-Dawley rat brain injected with Type 1 human alpha synuclein Pre-formed fibrils (SPR-322)Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).

  • StressXpress® Alpha-B Crystallin ELISA Kit

    Colorimetric detection of Alpha B Crystallin

    Catalog No. SKT-123

    5.00 out of 5 based on 1 customer rating
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    Species Reactivity Hu
    Sample Types Cell lysates, Serum, Tissue
    SKU: SKT-123 Categories: ,

    SKT-123_Alpha_B_Crystallin_ELISA_Kit_Standard_Curve.png

  • Alsterpaullone

    CDK, GSK Inhibitor

    Catalog No. SIH-431

    0 out of 5 based on 0 customer ratings
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    CAS No. 237430-03-4
    Molecular Formula C16H11N3O3
    SKU: SIH-431 Categories: ,

    SIH-431_Alsterpaullone_Chemical_Structure.png

  • Ambroxol HCl

    Free radical scavenger

    Catalog No. SIH-153

    0 out of 5 based on 0 customer ratings
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    CAS No. 23828-92-4
    Molecular Formula C13H18Br2N2O•HCl
    SKU: SIH-153 Categories: ,

    SIH-153_Ambroxol_HCl_Chemical_Structure.png

  • Amifostine

    HIF-1α activator

    Catalog No. SIH-210

    0 out of 5 based on 0 customer ratings
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    CAS No. 20537-88-6
    Molecular Formula C5H15N2O3PS
    SKU: SIH-210 Categories: ,

    SIH-210_Amifostine_Chemical_Structure.png

  • Amiodarone Hydrochloride

    Autophagy inducer

    Catalog No. SIH-393

    0 out of 5 based on 0 customer ratings
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    CAS No. 19774-82-4
    Molecular Formula C25H29I2NO3•HCl
    SKU: SIH-393 Categories: ,

    SIH-393_Amiodarone_Hydrochloride_Chemical_Structure.png

  • Amlodipine

    L-type Ca channel blocker

    Catalog No. SIH-315

    0 out of 5 based on 0 customer ratings
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    CAS No. 111470-99-6
    Molecular Formula C20H25ClN2O5•C6H5SO3H
    SKU: SIH-315 Categories: ,

    SIH-315_Amlodipine_Chemical_Structure.png

  • Andrographolide

    Apoptosis Inducer

    Catalog No. SIH-220

    0 out of 5 based on 0 customer ratings
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    CAS No. 5508-58-7
    Molecular Formula C20H30O5
    SKU: SIH-220 Categories: ,

    SIH-220_Andrographolide_Chemical_Structure.png

  • AP-18

    TRPA1 blocker

    Catalog No. SIH-310

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    CAS No. 55224-94-7
    Molecular Formula C11H12ClNO
    SKU: SIH-310 Categories: ,

    SIH-310_AP-18_Chemical_Structure.png

  • Apicidin

    HDAC inhibitor

    Catalog No. SIH-346

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    CAS No. 183506-66-3
    Molecular Formula C34H49N5O6
    SKU: SIH-346 Categories: ,

    SIH-346_Apicidin_Chemical_Structure.png

  • Apigenin

    Protein kinase inhibitor

    Catalog No. SIH-249

    0 out of 5 based on 0 customer ratings
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    CAS No. 520-36-5
    Molecular Formula C15H10O5
    SKU: SIH-249 Categories: ,

    SIH-249_Apigenin_Chemical_Structure.png

  • AR A014418

    GSK-3 kinase inhibitor

    Catalog No. SIH-492

    0 out of 5 based on 0 customer ratings
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    CAS No. 487021-52-3
    Molecular Formula C12H12N4O4S
    SKU: SIH-492 Categories: ,

    SIH-492_AR-A_014418_Chemical_Structure.png

  • AS 041164

    PI 3-Kgamma kinase inhibitor

    Catalog No. SIH-433

    0 out of 5 based on 0 customer ratings
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    CAS No. 6318-41-8
    Molecular Formula C11H7NO4S
    SKU: SIH-433 Categories: ,

    SIH-433_AS-041164_Chemical_Structure.png