StressMarq Biosciences is a leading provider of high-quality fibrillar, oligomeric, and monomeric protein preparations—including alpha synuclein, tau, amyloid beta, TDP-43, SOD1, TTR and more—designed to support cutting-edge neurodegenerative disease research. With a focus on pathology-inducing protein aggregates, our products support the development of robust disease models and accelerate drug discovery for conditions such as Alzheimer’s, Parkinson’s, and ALS. StressMarq is committed to scientific excellence— empowering researchers worldwide with tools that accelerate discovery and translational research.

Gamma Synuclein Pre-formed Fibrils (PFFs) & Monomers

Gamma synuclein is a presynaptic protein implicated in both neurodegenerative diseases and certain cancers. It has been shown to seed alpha synuclein aggregation and is associated with pathological protein oxidation and aggregation in disorders such as Parkinson’s disease, Dementia with Lewy Bodies (DLB), and Amyotrophic Lateral Sclerosis (ALS). These properties make gamma synuclein a valuable target for studying disease mechanisms involving protein misfolding, neurotoxicity, and synuclein cross-talk.

StressMarq Biosciences offers a selection of gamma synuclein protein constructs, optimized for neurodegeneration research. These reagents support investigations into synucleinopathy progression, oxidative stress, and cancer-related pathways, providing researchers with reliable tools for translational and mechanistic studies.

StressMarq manufactures wild-type gamma synuclein fibrils and monomers for use in neurodegenerative disease research.

• Human Recombinant Gamma Synuclein Pre-formed Fibrils (PFFs) | catalog# SPR-459
• Human Recombinant Gamma Synuclein Monomers | catalog# SPR-407

TEM of Active Human Recombinant Gamma Synuclein Protein Pre-formed Fibrils (catalog# SPR-459)

1. Surguchov A: Synucleins: are they two-edged swords? J Neurosci Res 2013, 91(2):16.
2. Galvin, J.E. Axon pathology in Parkinson’s disease and Lewy body dementia hippocampus contains a-, b-, and g-synuclein. Proc Natl Acad Sci USA. 1999 Nov 9; 96(23): 13450–13455.
3. Peters OM, Millership S, Shelkovnikova TA, et al. Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis. Neurobiol Dis 2012;48: 124–131.

Product Citations

StressMarq’s proteins for neurodegenerative disease research have been cited in many peer-reviewed scientific journals. 

• Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson’s disease. Mao, H. et al. Transl Neurodegener. Jul 2024.
  • Catalog# SPR-459: Human Recombinant Gamma Synuclein Pre-formed Fibrils (Type 1)

Supplemental Learning Materials

Technical Support Resources

• Handling Instructions | Synucleins
• Protocols | Neuro Proteins
• Sonication Protocol | PFFs
• Frequently Asked Questions | Neuro Proteins

Selected Publications from the StressMarq Blog

• Gamma Synuclein Aggregation in Neurodegenerative Diseases

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