Proteins

  • Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils: ATTO 488

    Human Recombinant Tau-441 (2N4R) P301S Mutant PFFs: ATTO 488

    Catalog No. SPR-329-A488

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    Expression System E. coli
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    SPR-329-A488_Tau-Protein-Protein-TEM-1.png
    TEM of ATTO conjugated tau pre-formed fibrilsThioflavin T assay of ATTO-488 conjugated tau fibrils

  • Tau-441 (2N4R) Wild-Type Monomers

    Human Recombinant Tau-441 (2N4R) Wild-Type Monomers

    Catalog No. SPR-479

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    Expression System E. coli
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    SPR-479_Tau-Protein-SDS-PAGE-1.png
    Thioflavin T assay of Tau Wild-Type fibrils (SPR-480) and monomers (SPR-479)

  • Tau-441 (2N4R) Wild-Type Monomers

    Human Recombinant Tau-441 (2N4R) Wild-Type Monomers (Baculovirus/Sf9)

    Catalog No. SPR-496

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    Expression System Baculovirus (Sf9)
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    SPR-496_Tau-441-2N4R-Wild-Type-Monomers-Baculovirus-Sf9-Protein-SDS-PAGE-1
    Dot Blot of Human Tau-441 (2N4R) Wild-Type Monomers (Baculovirus/Sf9) Protein (SPR-496)Mass Spec Table of Human Tau-441 (2N4R) Wild-Type Monomers (Baculovirus/Sf9) Protein (SPR-496)

  • Tau-441 (2N4R) Wild-Type Oligomers

    Human Recombinant Tau-441 (2N4R) Wild-Type Oligomers (Baculovirus/Sf9)

    Catalog No. SPR-497

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    Expression System Baculovirus (Sf9)
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    SPR-497_Tau-441-2N4R-Wild-Type-Oligomers-Protein-AFM-1.png
    Native-PAGE of Tau-441 (2N4R) Wild-Type Oligomers (SPR-497)Toxicity of Tau-441 (2N4R) Wild-Type Oligomers (SPR-497)SDS-Page of Tau-441 (2N4R) Wild-Type Oligomers (SPR-497)Dot Blot of Tau-441 (2N4R) Wild-Type Oligomers (SPR-497)

  • Tau-441 (2N4R) Wild-Type Pre-formed Fibrils

    Human Recombinant Tau-441 (2N4R) Wild-Type PFFs

    Catalog No. SPR-480

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    Expression System E. coli
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    SPR-480_Tau-Protein-TEM-1.png
    TEM of human recombinant tau wild-type PFFs (SPR-480)Thioflavin T assay of Tau Wild-Type fibrils (SPR-480) and monomers (SPR-479)

  • Tau-441 (2N4R) Wild-Type Pre-formed Fibrils

    Human Recombinant Tau-441 (2N4R) Wild-Type PFFs (Baculovirus/Sf9)

    Catalog No. SPR-498

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    Expression System Baculovirus (Sf9)
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    SPR-498_Tau-441-2N4R-Wild-Type-Pre-formed-Fibrils-Baculovirus-Sf9-Protein-TEM-1.png
    SDS-PAGE of Human Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9) Protein (SPR-498)Mass Spec Table of Human Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9) Protein (SPR-498)AFM of Human Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9) Protein (SPR-498)TEM of Human Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9) Protein (SPR-498)TEM of Human Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9) Protein (SPR-498)TEM of Human Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9) Protein (SPR-498)Toxicity of Human Tau-441 (2N4R) Wild-Type Pre-formed Fibrils (Baculovirus/Sf9) Protein (SPR-498)

  • TDP-43 Hexamutant (W→S) Monomers

    Human Recombinant TDP-43 (W68S, W113S, W172S, W334S, W385S, W412S) Mutant Monomers

    Catalog No. SPR-522

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    Expression System E. coli
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    SPR-522_TDP-43-Hexamutant-W→S-Monomers-Protein-SDS-Page-1.png

  • Transthyretin (TTR) L55P Variant Filaments

    Human Recombinant Transthyretin (TTR) L55P Variant Filaments

    Catalog No. SPR-464

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    SPR-464_TTR-Protein-Filaments-Protein-TEM-1.png

  • Transthyretin (TTR) L55P Variant Monomers

    Human Recombinant Transthyretin (TTR) L55P Variant Monomers

    Catalog No. SPR-451

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    SPR-451_Transthyretin-Protein-SDS-PAGE-1.png

  • Transthyretin (TTR) Y78F Variant Filaments

    Human Recombinant Transthyretin (TTR) Y78F Variant Filaments

    Catalog No. SPR-465

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    SPR-465_TTR-Protein-Filaments-Protein-Turbidity-Assay-1.png

  • Transthyretin (TTR) Y78F Variant Monomers

    Human Recombinant Transthyretin (TTR) Y78F Variant Monomers

    Catalog No. SPR-452

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    SPR-452_Transthyretin-Protein-SDS-PAGE-1.png

  • MOLECULAR SIGNATURE® 4-Hydroxy-2-hexenal BSA Conjugate

    Bovine Serum Albumin (BSA) modified with 4-Hydroxy-2-hexenal (4-HHE)

    Catalog No. SPR-210

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    Expression System Synthetic
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    SPR-210_4-Hydroxy-2-hexenal-BSA-Conjugate-Protein-Western-Blot-1.png

  • MOLECULAR SIGNATURE® 4-Hydroxynonenal BSA Conjugate

    Bovine Serum Albumin (BSA) modified with 4-Hydroxy nonenal (4-HNE)

    Catalog No. SPR-211

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    Expression System Synthetic
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    SPR-211_4-Hydroxynonenal-BSA-Conjugate-Protein-Western-Blot-1.png

  • MOLECULAR SIGNATURE® Acrolein BSA Conjugate

    Bovine Serum Albumin (BSA) modified with Acrolein

    Catalog No. SPR-206

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    Expression System Synthetic
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    SPR-206_Acrolein-BSA-Conjugate-Protein-Western-Blot-1.png

  • AHA1 Protein

    Human Recombinant AHA1 Protein

    Catalog No. SPR-300

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    Expression System E. coli
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    SPR-300_AHA1_Protein_SDS-Page.png

  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 2)

    Catalog No. SPR-316

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    SPR-316_Alpha-Synuclein-Protein-Monomer-Protein-SDS-Page-1.png
    Alpha Synuclein monomers (SPR-316) do not form new alpha synuclein fibrils when combined with Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by a limited increase in fluorescence intensity by Thioflavin T over time.Alpha Synuclein Monomer RT-QuiC AssayΑlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.LDH assay shows effect of alpha synuclein monomers on mouse primary neuronsMTT assay shows effects of alpha synuclein monomers on mouse primary neurons