Products

  • Tau-352 (fetal 0N3R) Wild-Type Monomers

    Human Recombinant Tau-352 (fetal 0N3R) Wild-Type Monomers

    Catalog No. SPR-490

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    Expression System E. coli
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    SKU: SPR-490 Category:

    SPR-490_Tau-352-fetal-0N3R-Wild-Type-Monomers-Protein-SDS-Page-1.png
    Thioflavin T assay of  Tau-352 (fetal 0N3R) Wild-Type Monomers Protein (SPR-490)
  • Tau-352 (fetal 0N3R) Wild-Type Pre-formed Fibrils

    Human Recombinant Tau-352 (fetal 0N3R) Wild-Type PFFs

    Catalog No. SPR-491

    5.00 out of 5 based on 1 customer rating
    Expression System E. coli
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    SKU: SPR-491 Category:

    SPR-491_Tau-352-fetal-0N3R-Wild-Type-Pre-formed-Fibrils-Protein-TEM-1.png
    AFM of  Tau-352 (fetal 0N3R) Wild-Type Pre-formed Fibrils Protein (SPR-491)SDS-Page of  Tau-352 (fetal 0N3R) Wild-Type Pre-formed Fibrils Protein (SPR-491)Thioflavin T assay of  Tau-352 (fetal 0N3R) Wild-Type Pre-formed Fibrils Protein (SPR-491)
  • Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils

    Human Amyloid Beta Pyroglutamate 3-42 PFFs

    Catalog No. SPR-492

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    Expression System Synthetic
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    SKU: SPR-492 Category:

    SPR-492_Amyloid-Beta-Pyroglutamate-3-42-Pre-formed-Fibrils-Protein-TEM-1.png
    AFM of  Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils Protein (SPR-492)Western Blot of  Amyloid Beta Pyroglutamate 3-42 Pre-formed Fibrils Protein (SPR-492)
  • Tau and Alpha Synuclein Co-Polymer Fibrils

    Human Recombinant Tau-352 (fetal 0N3R) and Human Recombinant Alpha Synuclein Co-Polymer Fibrils

    Catalog No. SPR-494

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    Expression System E. coli
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    SKU: SPR-494 Category:

    SPR-494_Tau-and-Alpha-Synuclein-co-polymer-fibrils-Protein-TEM-1.png
    Immuno-TEM of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-494)SDS-Page of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-494)Thioflavin T assay of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-494)
  • Tau and Alpha Synuclein Co-Polymer Fibrils

    Human Recombinant Tau-441 (2N4R) and Human Recombinant Alpha Synuclein Co-Polymer Fibrils

    Catalog No. SPR-495

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    Expression System E. coli
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    SKU: SPR-495 Category:

    SPR-495_Tau-and-Alpha-Synuclein-co-polymer-fibrils-Protein-TEM-1.png
    Immuno-TEM of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-495)SDS-Page of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-495)Thioflavin T assay of Human Tau and Alpha Synuclein co-polymer fibrils Protein (SPR-495)
  • Alpha Synuclein Oligomers

    Human Recombinant Alpha Synuclein Oligomers (Epigallocatechin gallate (EGCG) Stabilized)

    Catalog No. SPR-469

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    Expression System E. coli
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    SKU: SPR-469 Category:

    SPR-469_Alpha-Synuclein-Oligomers-Protein-TEM-1.png
    Thioflavin T assay shows that EGCG-stabilzed alpha synuclein oligomers do not seed aggregation of alpha synuclein monomersSDS-PAGE of EGCG-stabilized alpha synuclein oligomers (SPR-469)Native SDS-PAGE of EGCG-stabilized alpha synuclein oligomers (SPR-469)
  • Alpha Synuclein Pre-formed Fibrils: ATTO 594

    Human Recombinant Alpha Synuclein PFFs: ATTO 594 (Type 1)

    Catalog No. SPR-322-A594

    5.00 out of 5 based on 1 customer rating
    Expression System E. coli
    Tags ATTO 594
    SKU: SPR-322-A594 Category:

    SPR-322-A594_Alpha-Synuclein-Protein-Protein-TEM-1.png
    Thioflavin T Assay for SPR-322-A594Human iPSC-derived neurons seeded with ATTO594 labelled alpha synuclein PFFs (SPR-322-A594)TEM of ATTO conjugated alpha syuclein pre-formed fibrils
  • Amyloid Beta 1-42 Oligomers

    Human Synthetic Amyloid Beta 1-42 Oligomers

    Catalog No. SPR-488

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    Expression System Synthetic
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    SKU: SPR-488 Category:

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    SPR-488_Amyloid-Beta-1-42-Oligomers-Protein-TEM-3_panel.png
    WB of Amyloid Beta Peptide Protein (Monomers, Oligomers, and PFFS) (SPR-485, SPR-488, SPR-487)Toxicity of Amyloid Beta Peptide Protein (Monomers, Oligomers, and PFFS) (SPR-485, SPR-488, SPR-487)AFM of Amyloid Beta Peptide Protein (Monomers, Oligomers, and PFFS) (SPR-485, SPR-488, SPR-487)
  • Tau-441 (2N4R) P301S Mutant Monomers

    Human Recombinant Tau-441 (2N4R) P301S Mutant Monomers

    Catalog No. SPR-327

    5.00 out of 5 based on 1 customer rating
    Expression System E. coli
    Tags No tag
    SKU: SPR-327 Category:

    SPR-327_Tau-Protein-Monomer-SDS-PAGE-1.png
    Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time in active tau monomers (SPR-327).  A greater increase in fluorescence is seen when 50 μM active monomer (SPR-327) is combined with 10 μM of active fibrils (SPR-329 or SPR-330), as the active fibrils seed the formation of new fibrils from the pool of active monomers.
  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 1)

    Catalog No. SPR-322

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    Expression System E. coli
    Tags No tag
    SKU: SPR-322 Category:

    SPR-322_Alpha-Synuclein-Protein-Preformed-Fibrils-Protein-TEM-7.png
    Αlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)StressMarq’s Alpha Synuclein PFFs (red) cat#SPR-322, were shown to be taken up by SH-SY5Y cells and transmitted to neuronal iPSCs within 14 days.SDS-Page of Type 1 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-322)Type 1 alpha synuclein Pre-formed fibrils (SPR-322) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) as shown by increased fluorescence intensity by Thioflavin T over time.Immunocytochemistry/Immunofluorescence of Human Alpha Synuclein Protein Protein (SPR-322)Mouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFsMouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFs cause endogenous alpha synuclein phosphorylationTEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-322)IHC of Sprague-Dawley rat brain injected with Type 1 human alpha synuclein Pre-formed fibrils (SPR-322)Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).