Products

  • Tau-410 (2N3R) Wild-Type Pre-formed Fibrils

    Human Recombinant Tau-410 (2N3R) Wild-Type PFFs

    Catalog No. SPR-535

    0 out of 5 based on 0 customer ratings
    Reviews (0)
    Expression System E. coli
    Tags No tag
    SKU: SPR-535 Category:

    Bulk Quote
    SPR-535_Tau-410-2N3R-Wild-Type-Pre-formed-Fibrils-Protein-SDS-PAGE-1.png
    AFM of Tau-410 (2N3R) Wild-Type Pre-formed Fibrils (SPR-535)Thioflavin T assay of Tau-410 (2N3R) Wild-Type Pre-formed Fibrils (SPR-535)Sedimentation assay of Tau-410 (2N3R) Wild-Type Pre-formed Fibrils (SPR-535)Western Blot of Tau-410 (2N3R) Wild-Type Pre-formed Fibrils (SPR-535)

  • Tau-410 (2N3R) Wild-Type Monomers

    Human Recombinant Tau-410 (2N3R) Wild-Type Monomers

    Catalog No. SPR-534

    0 out of 5 based on 0 customer ratings
    Reviews (0)
    Expression System E. coli
    Tags No tag
    SKU: SPR-534 Category:

    Bulk Quote
    SPR-534_Tau-410-2N3R-Wild-Type-Monomers-Protein-SDS-PAGE-1.png
    Thioflavin T assay of Tau-410 (2N3R) Wild-Type Monomers (SPR-534)Western Blot of Tau-410 (2N3R) Wild-Type Monomers (SPR-534)

  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 2)

    Catalog No. SPR-316

    0 out of 5 based on 0 customer ratings
    Reviews (0)
    Expression System E. coli
    Tags No tag
    SKU: SPR-316 Category:

    Bulk Quote
    SPR-316_Alpha-Synuclein-Protein-Monomer-Protein-SDS-Page-1.png
    Alpha Synuclein monomers (SPR-316) do not form new alpha synuclein fibrils when combined with Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by a limited increase in fluorescence intensity by Thioflavin T over time.Alpha Synuclein Monomer RT-QuiC AssayΑlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.LDH assay shows effect of alpha synuclein monomers on mouse primary neuronsMTT assay shows effects of alpha synuclein monomers on mouse primary neurons

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 2)

    Catalog No. SPR-317

    5.00 out of 5 based on 2 customer ratings
    Reviews (2)
    Expression System E. coli
    Tags No tag
    SKU: SPR-317 Category:

    Bulk Quote
    SPR-317_Alpha-Synuclein-Preformed-Fibrils-Protein-TEM-4.png
    TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-317)Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.SDS-Page of Type 2 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-317)Type 2 alpha synuclein Pre-formed fibrils (SPR-317) do not seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) at the same rate as Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by lower fluorescence intensity values of Thioflavin T over time.Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)LDH assay shows effect of alpha synuclein PFFs on mouse primary neuronsMTT assay effects of alpha synuclein PFFs on mouse primary neurons

  • Alpha Synuclein Monomers

    Human Recombinant Alpha Synuclein Monomers (Type 1)

    Catalog No. SPR-321

    5.00 out of 5 based on 1 customer rating
    Reviews (1)
    Expression System E. coli
    Tags No tag
    SKU: SPR-321 Category:

    Bulk Quote
    SPR-321_Alpha-Synuclein-Protein-Monomer-Thioflavin-T-assay-1.png
    SDS-Page of huma alpha synuclein monomer (SPR-321)

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 1)

    Catalog No. SPR-322

    5.00 out of 5 based on 1 customer rating
    Reviews (1)
    Expression System E. coli
    Tags No tag
    SKU: SPR-322 Category:

    Bulk Quote
    SPR-322_Alpha-Synuclein-Protein-Preformed-Fibrils-Protein-TEM-7.png
    Αlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)StressMarq’s Alpha Synuclein PFFs (red) cat#SPR-322, were shown to be taken up by SH-SY5Y cells and transmitted to neuronal iPSCs within 14 days.SDS-Page of Type 1 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-322)Type 1 alpha synuclein Pre-formed fibrils (SPR-322) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) as shown by increased fluorescence intensity by Thioflavin T over time.Immunocytochemistry/Immunofluorescence of Human Alpha Synuclein Protein Protein (SPR-322)Mouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFsMouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFs cause endogenous alpha synuclein phosphorylationTEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-322)IHC of Sprague-Dawley rat brain injected with Type 1 human alpha synuclein Pre-formed fibrils (SPR-322)Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).