Products

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 1)

    Catalog No. SPR-322

    5.00 out of 5 based on 1 customer rating
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    Expression System E. coli
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    SKU: SPR-322 Category:

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    SPR-322_Alpha-Synuclein-Protein-Preformed-Fibrils-Protein-TEM-7.png
    Αlpha Synuclein Oligomers Have Distinct Secondary Structure Differences Compared to Fibrils.Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)ICC/IF of human Alpha Synuclein Protein Preformed Fibrils Protein (SPR-322)StressMarq’s Alpha Synuclein PFFs (red) cat#SPR-322, were shown to be taken up by SH-SY5Y cells and transmitted to neuronal iPSCs within 14 days.SDS-Page of Type 1 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-322)Type 1 alpha synuclein Pre-formed fibrils (SPR-322) seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) as shown by increased fluorescence intensity by Thioflavin T over time.Immunocytochemistry/Immunofluorescence of Human Alpha Synuclein Protein Protein (SPR-322)Mouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFsMouse neurocortical primary cells seeded with fluorescently-labelled alpha synuclein PFFs cause endogenous alpha synuclein phosphorylationTEM of Type 1 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-322)IHC of Sprague-Dawley rat brain injected with Type 1 human alpha synuclein Pre-formed fibrils (SPR-322)Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).

  • Alpha Synuclein Pre-formed Fibrils

    Human Recombinant Alpha Synuclein PFFs (Type 2)

    Catalog No. SPR-317

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    Expression System E. coli
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    SKU: SPR-317 Category:

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    SPR-317_Alpha-Synuclein-Preformed-Fibrils-Protein-TEM-4.png
    TEM of Type 2 Alpha Synuclein Pre-formed Fibrils (PFFs) (SPR-317)Alpha Synuclein Pre-formed Fibrils (PFF), Type 1 (cat#SPR-322) and Type 2 (cat#SPR-317) do have small secondary structure differences.SDS-Page of Type 2 Human Recombinant Alpha Synuclein Protein Pre-formed Fibrils (SPR-317)Type 2 alpha synuclein Pre-formed fibrils (SPR-317) do not seed the formation of new alpha synuclein fibrils from the pool of alpha synuclein monomers (SPR-321) at the same rate as Type 1 alpha synuclein Pre-formed fibrils (SPR-322) as shown by lower fluorescence intensity values of Thioflavin T over time.Primary rat hippocampal neurons show lewy body inclusion formation when treated with Type 1 Alpha Synuclein Protein Pre-formed Fibrils (SPR-322) (D-F), but not when treated with Type 2 Alpha Synuclein Protein Pre-formed Fibrils (SPR-317) (A-C).Toxicity results comparing Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 2) and Active Human Recombinant Alpha Synuclein Pre-formed Fibrils (Type 1)LDH assay shows effect of alpha synuclein PFFs on mouse primary neuronsMTT assay effects of alpha synuclein PFFs on mouse primary neurons

  • Stattic

    STAT3 inhibitor

    Catalog No. SIH-554

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    CAS No. 19983-44-9
    Molecular Formula C8H5NO4S
    SKU: SIH-554 Categories: ,

    SIH-554-Stattic-Chemical-Structure.png

  • Oleamide

    Endogenous Sleep-inducing Lipid

    Catalog No. SIH-627

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    CAS No. 301-02-0
    Molecular Formula C18H35NO
    SKU: SIH-627 Categories: ,

    SIH-627-Oleamide-Chemical-Structure.png

  • Tau (K18) Wild-Type Monomers

    Human Recombinant Tau (K18) Wild-Type Monomers

    Catalog No. SPR-524

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    Expression System E. coli
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    SPR-524_Tau-K18-Wild-Type-Monomers-Protein-SDS-Page-1.png
    Thioflavin T assay of Human Tau (K18) Wild-Type Monomers Protein (SPR-524)

  • Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils: ATTO 488

    Human Recombinant Tau-441 (2N4R) P301S Mutant PFFs: ATTO 488

    Catalog No. SPR-329-A488

    5.00 out of 5 based on 1 customer rating
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    Expression System E. coli
    Tags ATTO 488
    SKU: SPR-329-A488 Category:

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    SPR-329-A488_Tau-Protein-Protein-TEM-1.png
    TEM of ATTO conjugated tau pre-formed fibrilsThioflavin T assay of ATTO-488 conjugated tau fibrils

  • Anti-ATG9B Antibody

    Rabbit Anti-Human ATG9B Polyclonal

    Catalog No. SPC-646

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    Species Reactivity Hu, Rt
    Applications WB IHC ICC/IF FCM IP
    SKU: SPC-646 Categories: ,

    SPC-646_ATG9B_Antibody_ICC-IF_Human_SK-N-BE-Cells-Human-Neuroblastoma-cells_60X_Composite_1.png
    Rabbit Anti-ATG9B Antibody used in Western blot (WB) on Brain cell lysates (SPC-646)

  • Anti-Calreticulin Antibody

    Rabbit Anti-Human Calreticulin Polyclonal

    Catalog No. SPC-122

    5.00 out of 5 based on 1 customer rating
    Reviews (1)
    Species Reactivity Hu, Ms, Rt, Bv, Dg, Ck, GP, Mk, Pg, Hm, Rb, Sh
    Applications WB IHC ICC/IF FCM IP
    SKU: SPC-122 Categories: ,

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    SPC-122_Calreticulin_Antibody_ICC-IF_Human_Heat-Shocked-HeLa-Cells_100x_Composite.png
    Rabbit Anti-Calreticulin Antibody used in Western blot (WB) on multiple cell lines lysates (SPC-122)Rabbit Anti-Calreticulin Antibody used in Immunohistochemistry (IHC) on Mouse backskin (SPC-122)Rabbit Anti-Calreticulin Antibody used in Immunocytochemistry/Immunofluorescence (ICC/IF) on Human Heat Shocked Cervical cancer cell line (HeLa) (SPC-122)

  • MS-275

    HDAC inhibitor

    Catalog No. SIH-416

    0 out of 5 based on 0 customer ratings
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    CAS No. 209783-80-2
    Molecular Formula C21H20N4O3
    SKU: SIH-416 Categories: ,

    SIH-416_MS_275_Chemical_Structure.png

  • Tau-441 (2N4R) P301S Mutant Pre-formed Fibrils

    Human Recombinant Tau-441 (2N4R) P301S Mutant PFFs

    Catalog No. SPR-329

    5.00 out of 5 based on 1 customer rating
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    Expression System E. coli
    Tags No tag
    SKU: SPR-329 Category:

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    SPR-329_Tau-Protein-Peformed-Fibrils-TEM-1.png
    TEM of recombinant Tau441 (2N4R), P301S mutant Pre-formed Fibrils (PFFs)Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) when tau Pre-formed fibrils (SPR-329) are combined with tau monomers (SPR-327). The Pre-formed fibrils seed the formation of new fibrils from a pool of monomers.SDS-PAGE of ~67 kDa Human Tau 2N4R P301S Pre-formed Fibrils (PFFs)