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| Product Name | TTNPB |
| Description |
Retinoic acid receptor agonist |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 71441-28-6 |
| Molecular Formula | C24H28O2 |
| Molecular Weight | 348.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | May be dissolved in DMSO (4 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | CC(=CC1=CC=C(C=C1)C(=O)O)C2=CC3=C(C=C2)C(CCC3(C)C)(C)C |
| InChI | InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ |
| InChIKey | FOIVPCKZDPCJJY-JQIJEIRASA-N |
| Safety Phrases |
Classification: Danger. Hazard Statements H315 - H319 - H335 - H360 Precautionary Statements P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313 |
| Cite This Product | TTNPB (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-608) |
Biological Description
| Alternative Names | 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid; Ro 13-7410; AGN-191183 |
| Research Areas | Apoptosis, Cancer, Stem Cells |
| PubChem ID | 5289501 |
| Scientific Background | TTNPB is a potent analog of retinoic acid that selectively activates retinoic acid receptors (RARs). It enables chemical reprogramming of somatic cells to induced pluripotent stem cells and promotes differentiation of myeloid progenitors. In neuroscience, TTNPB is used to study neural differentiation, stem cell reprogramming, and retinoic acid signaling pathways, which are critical for neurodevelopment and regeneration in neurodegenerative disease models. |
| References | 1. Beard R.L., et al. (1995) J Med Chem. 38 (15): 2820-2829. 2. Hou P. et al. (2013) Science. 341 (6146): 651-654. 3. Fabian I. (1987) Leukemia Research. 11 (7): 635-640. |
Product Images
Chemical structure of TTNPB (SIH-608), a Retinoid RAR agonist. CAS #: 71441-28-6. Molecular Formula: C24H28O2. Molecular Weight: 348.5 g/mol.
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