Ferrostatin-1

Ferroptosis Inhibitor

Catalog No. SIH-525

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CAS No. 347174-05-4
Molecular Formula C15H22N2O2
SKU: SIH-525 Categories: ,

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SIH-525_Ferrostatin_1_Chemical_Structure.png
Product Name Ferrostatin-1
Description

Ferroptosis Inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 347174-05-4
Molecular Formula C15H22N2O2
Molecular Weight 262.4
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (100 mg/ml) or ethanol (100 mg/ml)
Source Synthetic
Appearance Tan powder
SMILES CCOC(=O)c1ccc(c(c1)N)NC2CCCCC2
Safety Phrases Classification:
Skin irritation (Category 2), H315

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray P264 Wash skin thoroughly after handling.
P280 Wear protective gloves.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + 340 If INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P305 + 351+ + 338 IF IN EYES: Rinse continuously with water for several minutes. Remove contact lenses if present and easy to do so- continue rinsing.
P333 + 313 If skin irritation or a rash occurs: Get medical advice/attention
Cite This Product Ferrostatin-1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-525)

Biological Description

Alternative Names Ethyl 3-amino-4-(cyclohexylamino)benzoate
Research Areas Apoptosis, Cancer, Cell Signaling, Neuroscience
Scientific Background Ferrostatin-1 inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death. It is especially potent of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices (1). It also blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells (2), and inhibits oxidative lipid damage and cell death in diverse disease models (3).
References 1. Dixon S.J., et al. (2012) Cell. 149: 1060.
2. Louandre C., et al. (2013) Int. J. Cancer. 133: 1732.
3. Skouta R., et al. (2014) J. Am. Chem. Soc. 136: 4551.

Product Images

<p>Chemical structure of Ferrostatin-1 (SIH-525), a Ferroptosis Inhibitor. CAS #: 347174-05-4. Molecular Formula: C15H22N2O2. Molecular Weight: 262.4 g/mol.</p>

Chemical structure of Ferrostatin-1 (SIH-525), a Ferroptosis Inhibitor. CAS #: 347174-05-4. Molecular Formula: C15H22N2O2. Molecular Weight: 262.4 g/mol.

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