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| Product Name | Andrographolide |
| Description |
Apoptosis Inducer |
| Purity | >98% |
| CAS No. | 5508-58-7 |
| Molecular Formula | C20H30O5 |
| Molecular Weight | 350.45 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | DMSO |
| Source | Synthetic |
| Appearance | Off-white Solid |
| SMILES | OC3COC(=O)C3=CC[C@@H]1C(=C)CC[C@@H]2C(C)(CO)[C@H](O)CC[C@@]12C |
| InChI | InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6 |
| InChIKey | BOJKULTULYSRAS-OTESTREVSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Andrographolide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-220) |
Biological Description
| Alternative Names | (3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}dihydro-2(3H)-furanone |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 5318517 |
| Scientific Background | Andrographolide is a labdane diterpenoid derived from Andrographis paniculata, known for its anti-inflammatory and immunomodulatory effects. In neuroscience, it has been investigated for its ability to inhibit T-cell proliferation and macrophage chemotaxis, processes implicated in neuroinflammation. These properties suggest potential utility in modulating immune responses in neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease. |
| References |
1. Chakravarti R.N., Chakravarti D. (1951) Ind. Med Gaz. 86(3): 96-7. 2. Tsai H.R., et al. (2004) Eur J Pharmacol. 498: 45-52. 3. Rajagopal S., et al. (2003) J Exp. Ther. Oncol. 3: 147-158. |
Product Images
Chemical structure of Andrographolide (SIH-220), a Induces mitochondrial -mediated apoptosis in lymphoma cells. CAS #: 5508-58-7. Molecular Formula: C20H30O5. Molecular Weight: 350.45 g/mol.
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