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| Product Name | Docetaxel |
| Description |
Microtubule stabilizer |
| Purity | >98% |
| CAS No. | 114977-28-5 |
| Molecular Formula | C43H53NO14 |
| Molecular Weight | 807.88 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inducer |
| Solubility | Soluble to 100 mM in DMSO, and to 100 mM in ethanol |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O |
| InChI | InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47) |
| InChIKey | ZDZOTLJHXYCWBA-VCVYQWHSSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Docetaxel (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-240) |
Biological Description
| Alternative Names | (2α,5β,7β,10β,13α)-4-Acetoxy-1,7,10-trihydroxy-13-{[(2R,3S)-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 148124 |
| Scientific Background | Docetaxel is a semi-synthetic analogue of paclitaxel that binds and stabilizes microtubules, resulting in cell cycle arrest and apoptosis. In neurodegenerative disease research, docetaxel is used to investigate microtubule-targeting strategies and their effects on neuronal integrity. Its ability to interfere with mitotic processes and induce apoptosis has made it a valuable tool in understanding neurotoxicity and axonal degeneration. |
| References |
1. Clarke S.J., and Rivory L.P. (1999) Clin Pharmacokinet. 36(2): 99-114. 2. Woodward E.J. and Twelves C. (2010) Curr. Clin Pharmacol. 5(3): 226-231. |
Product Images
Chemical structure of Docetaxel (SIH-240), a Microtubule stabilizing agent. CAS #: 114977-28-5. Molecular Formula: C43H53NO14. Molecular Weight: 807.88 g/mol.
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