Docetaxel

Microtubule stabilizer

Catalog No. SIH-240

0 out of 5 based on 0 customer ratings
CAS No. 114977-28-5
Molecular Formula C43H53NO14
SKU: SIH-240 Categories: ,

Clear
SIH-240_Docetaxel_Chemical_Structure.png
Product Name Docetaxel
Description

Microtubule stabilizer

Purity >98%
CAS No. 114977-28-5
Molecular Formula C43H53NO14
Molecular Weight 807.88
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inducer
Solubility Soluble to 100 mM in DMSO, and to 100 mM in ethanol
Source Synthetic
Appearance White solid
SMILES CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)
InChIKey ZDZOTLJHXYCWBA-VCVYQWHSSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product Docetaxel (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-240)

Biological Description

Alternative Names (2α,5β,7β,10β,13α)-4-Acetoxy-1,7,10-trihydroxy-13-{[(2R,3S)-2-hydroxy-3-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
Research Areas Apoptosis, Cancer
PubChem ID 148124
Scientific Background Docetaxel is a semi-synthetic analogue of paclitaxel that binds and stabilizes microtubules, resulting in cell cycle arrest and apoptosis. In neurodegenerative disease research, docetaxel is used to investigate microtubule-targeting strategies and their effects on neuronal integrity. Its ability to interfere with mitotic processes and induce apoptosis has made it a valuable tool in understanding neurotoxicity and axonal degeneration.
References 1. Clarke S.J., and Rivory L.P. (1999) Clin Pharmacokinet. 36(2): 99-114.
2. Woodward E.J. and Twelves C. (2010) Curr. Clin Pharmacol. 5(3): 226-231.

Product Images

<p>Chemical structure of Docetaxel (SIH-240), a Microtubule stabilizing agent. CAS #: 114977-28-5. Molecular Formula: C43H53NO14. Molecular Weight: 807.88 g/mol.</p>

Chemical structure of Docetaxel (SIH-240), a Microtubule stabilizing agent. CAS #: 114977-28-5. Molecular Formula: C43H53NO14. Molecular Weight: 807.88 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “Docetaxel”

Your email address will not be published. Required fields are marked *